| |  Online-Ressource |
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| Verfasst von: | Lo, Chun-Han [VerfasserIn]  |
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| | Kwon, Sohee [VerfasserIn] |
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| | Wang, Liang [VerfasserIn] |
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| | Polychronidis, Georgios [VerfasserIn] |
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| | Knudsen, Markus D. [VerfasserIn] |
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| | Zhong, Rong [VerfasserIn] |
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| | Cao, Yin [VerfasserIn] |
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| | Wu, Kana [VerfasserIn] |
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| | Ogino, Shuji [VerfasserIn] |
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| | Giovannucci, Edward L. [VerfasserIn] |
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| | Chan, Andrew T. [VerfasserIn] |
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| | Song, Mingyang [VerfasserIn] |
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| Titel: | Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma |
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| Titelzusatz: | a prospective study |
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| Verf.angabe: | Chun-Han Lo, Sohee Kwon, Liang Wang, Georgios Polychronidis, Markus D. Knudsen, Rong Zhong, Yin Cao, Kana Wu, Shuji Ogino, Edward L. Giovannucci, Andrew T. Chan, Mingyang Song |
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| Jahr: | 2021 |
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| Umfang: | 2 S. |
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| Teil: | volume:70 |
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| | year:2021 |
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| | number:3 |
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| | pages:620-621 |
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| | extent:2 |
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| Fussnoten: | Published online first 20 July 2020 ; Gesehen am 26.08.2021 |
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| Titel Quelle: | Enthalten in: Gut |
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| Ort Quelle: | London : BMJ Publishing Group, 1960 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 70(2021), 3, Seite 620-621 |
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| ISSN Quelle: | 1468-3288 |
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| Abstract: | We read with great interest the study by Coker et al 1 that provided supportive evidence for the role of oral microbiota in gastric cancer. A few studies also highlighted the possible link with oesophageal cancer.2-4 However, there is a lack of robust epidemiologic data on whether periodontal disease and tooth loss, indicators of oral microbial dysbiosis, are associated with these two cancers. - - Here, we prospectively examined the association of history of periodontal disease and tooth loss with the risk of oesophageal and gastric adenocarcinoma in 98 459 women from the Nurses’ Health Study (1992-2014) and 49 685 men from the Health Professionals Follow-up Study (1988-2016). Dental measures, demographics, lifestyle, and diet were assessed using validated follow-up questionnaires. Self-reported cancer diagnosis was confirmed by review of medical records. We used Cox proportional hazards models to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). We also examined the independent association of history of periodontal disease and tooth loss in a joint analysis. - - Over 22-28 years of follow-up, we documented 199 cases of oesophageal adenocarcinoma and 238 cases of gastric adenocarcinoma. History of periodontal disease was associated with a 43% and 52% increased risk of oesophageal adenocarcinoma (multivariable-adjusted HR (aHR) 1.43, 95% CI 1.05 to 1.96) and gastric adenocarcinoma (aHR 1.52, 95% CI 1.13 to 2.04) (table … |
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| DOI: | doi:10.1136/gutjnl-2020-321949 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1136/gutjnl-2020-321949 |
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| | Volltext: https://gut.bmj.com/content/70/3/620 |
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| | DOI: https://doi.org/10.1136/gutjnl-2020-321949 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | gastric cancer |
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| | oesophageal cancer |
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| K10plus-PPN: | 1753626250 |
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| Verknüpfungen: | → Zeitschrift |
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Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma / Lo, Chun-Han [VerfasserIn]; 2021 (Online-Ressource)
