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| Verfasst von: | Xydia, Maria [VerfasserIn]  |
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| | Rahbari, Raheleh [VerfasserIn] |
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| | Ruggiero, Eliana [VerfasserIn] |
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| | Macaulay, Iain [VerfasserIn] |
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| | Tarabichi, Maxime [VerfasserIn] |
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| | Lohmayer, Robert [VerfasserIn] |
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| | Wilkening, Stefan [VerfasserIn] |
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| | Michels, Tillmann [VerfasserIn] |
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| | Brown, Daniel [VerfasserIn] |
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| | Vanuytven, Sebastiaan [VerfasserIn] |
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| | Mastitskaya, Svetlana [VerfasserIn] |
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| | Laidlaw, Sean [VerfasserIn] |
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| | Grabe, Niels [VerfasserIn] |
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| | Pritsch, Maria [VerfasserIn] |
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| | Fronza, Raffaele [VerfasserIn] |
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| | Hexel, Klaus [VerfasserIn] |
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| | Schmitt, Steffen [VerfasserIn] |
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| | Müller-Steinhardt, Michael [VerfasserIn] |
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| | Halama, Niels [VerfasserIn] |
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| | Domschke, Christoph [VerfasserIn] |
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| | Schmidt, Manfred [VerfasserIn] |
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| | Kalle, Christof von [VerfasserIn] |
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| | Schütz, Florian [VerfasserIn] |
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| | Voet, Thierry [VerfasserIn] |
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| | Beckhove, Philipp [VerfasserIn] |
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| Titel: | Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients |
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| Verf.angabe: | Maria Xydia, Raheleh Rahbari, Eliana Ruggiero, Iain Macaulay, Maxime Tarabichi, Robert Lohmayer, Stefan Wilkening, Tillmann Michels, Daniel Brown, Sebastiaan Vanuytven, Svetlana Mastitskaya, Sean Laidlaw, Niels Grabe, Maria Pritsch, Raffaele Fronza, Klaus Hexel, Steffen Schmitt, Michael Müller-Steinhardt, Niels Halama, Christoph Domschke, Manfred Schmidt, Christof von Kalle, Florian Schütz, Thierry Voet & Philipp Beckhove |
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| E-Jahr: | 2021 |
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| Jahr: | 18 February 2021 |
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| Umfang: | 18 S. |
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| Fussnoten: | Gesehen am 11.08.2021 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 12(2021), Artikel-ID 1119, Seite 1-18 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Regulatory CD4+ T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers remain largely unclear. Here, we analyze Treg clonal origin in breast cancer patients using T-Cell Receptor and single-cell transcriptome sequencing. While Treg in peripheral blood and breast tumors are clonally distinct, Tconv clones, including tumor-antigen reactive effectors (Teff), are detected in both compartments. Tumor-infiltrating CD4+ cells accumulate into distinct transcriptome clusters, including early activated Tconv, uncommitted Teff, Th1 Teff, suppressive Treg and pro-tumorigenic Treg. Trajectory analysis suggests early activated Tconv differentiation either into Th1 Teff or into suppressive and pro-tumorigenic Treg. Importantly, Tconv, activated Tconv and Treg share highly-expanded clones contributing up to 65% of intratumoral Treg. Here we show that Treg in human breast cancer may considerably stem from antigen-experienced Tconv converting into secondary induced Treg through intratumoral activation. |
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| DOI: | doi:10.1038/s41467-021-21297-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-021-21297-y |
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| | Volltext: https://www.nature.com/articles/s41467-021-21297-y |
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| | DOI: https://doi.org/10.1038/s41467-021-21297-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1753628806 |
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| Verknüpfungen: | → Zeitschrift |
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Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients / Xydia, Maria [VerfasserIn]; 18 February 2021 (Online-Ressource)
