| |  Online-Ressource |
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| Verfasst von: | Khaimov, Valeria [VerfasserIn]  |
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| | Hofmann, Sarah Ulrike [VerfasserIn] |
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| | Druffel-Augustin, Silke [VerfasserIn] |
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| | Mogk, Axel [VerfasserIn] |
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| | Tyedmers, Jens [VerfasserIn] |
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| | Stoecklin, Georg [VerfasserIn] |
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| | Bukau, Bernd [VerfasserIn] |
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| Titel: | Coordination of translational control and protein homeostasis during severe heat stress |
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| Verf.angabe: | Valeria Cherkasov, Sarah Hofmann, Silke Druffel-Augustin, Axel Mogk, Jens Tyedmers, Georg Stoecklin, and Bernd Bukau |
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| E-Jahr: | 2013 |
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| Jahr: | November 27, 2013 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 13.04.2021 |
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| Titel Quelle: | Enthalten in: Current biology |
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| Ort Quelle: | London : Current Biology Ltd., 1991 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 23(2013), 24, Seite 2452-2462 |
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| ISSN Quelle: | 1879-0445 |
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| Abstract: | Background - Exposure of cells to severe heat stress causes not only misfolding and aggregation of proteins but also inhibition of translation and storage of mRNA in cytosolic heat stress granules (heat-SGs), limiting newly synthesized protein influx into overloaded proteome repair systems. How these two heat stress responses connect is unclear. - Results - Here, we show that both S. cerevisiae and D. melanogaster heat-SGs contain mRNA, translation machinery components (excluding ribosomes), and molecular chaperones and that heat-SGs coassemble with aggregates of misfolded, heat-labile proteins. Components in these mixed assemblies exhibit distinct molecular motilities reflecting differential trapping. We demonstrate that heat-SG disassembly and restoration of translation activity during heat stress recovery is intimately linked to disaggregation of damaged proteins present in the mixed assemblies and requires Hsp104 and Hsp70 activity. - Conclusions - Chaperone-driven protein disaggregation directly coordinates timing of translation reinitiation with protein folding capacity during cellular protein quality surveillance, enabling efficient protein homeostasis. |
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| DOI: | doi:10.1016/j.cub.2013.09.058 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cub.2013.09.058 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0960982213012475 |
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| | DOI: https://doi.org/10.1016/j.cub.2013.09.058 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1753996627 |
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| Verknüpfungen: | → Zeitschrift |
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Coordination of translational control and protein homeostasis during severe heat stress / Khaimov, Valeria [VerfasserIn]; November 27, 2013 (Online-Ressource)
