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Verfasst von:Kaduthanam, Sajo [VerfasserIn]   i
 Gade, Stephan [VerfasserIn]   i
 Meister, Michael [VerfasserIn]   i
 Brase, Jan Christoph [VerfasserIn]   i
 Johannes, Marc [VerfasserIn]   i
 Dienemann, Hendrik [VerfasserIn]   i
 Warth, Arne [VerfasserIn]   i
 Schnabel, Philipp Albert [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
 Sültmann, Holger [VerfasserIn]   i
 Muley, Thomas [VerfasserIn]   i
 Kuner, Ruprecht [VerfasserIn]   i
Titel:Serum miR-142-3p is associated with early relapse in operable lung adenocarcinoma patients
Verf.angabe:Sajo Kaduthanam, Stephan Gade, Michael Meister, Jan C. Brase, Marc Johannes, Hendrik Dienemann, Arne Warth, Philipp A. Schnabel, Felix J.F. Herth, Holger Sültmann, Thomas Muley, Ruprecht Kuner
E-Jahr:2013
Jahr:11 February 2013
Umfang:5 S.
Teil:volume:80
 year:2013
 number:2
 month:05
 pages:223-227
 extent:5
Fussnoten:Gesehen am 13.04.2021
Titel Quelle:Enthalten in: Lung cancer
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1985
Jahr Quelle:2013
Band/Heft Quelle:80(2013), 2 vom: Mai, Seite 223-227
ISSN Quelle:1872-8332
Abstract:The outcome of resectable non-small cell lung cancer (NSCLC) is critically determined by metastatic spread: About 30-50% of early-stage NSCLC patients encounter tumour recurrence within 5 years after surgery. A biomarker-driven stratification of early-stage lung cancer with a high risk of recurrence may improve therapy management and patient care. The aim of this study was to identify microRNAs (miRNAs) in serum of patients associated with early relapse in pulmonary adenocarcinoma. Serum samples were collected from 204 patients before surgery. miRNA screening was done using qRT-PCR based low-density arrays (664 miRNAs) comparing adenocarcinoma patients (n=40) with and without recurrence 24 months after surgery. Selected miRNAs associated with disease recurrence were validated in an independent patient cohort (n=114). miRNAs were also measured in advanced adenocarcinoma patients (n=29), and individuals with benign pulmonary diagnosis (n=21). Circulating miR-142-3p (p=0.005) and miR-29b (p=0.01) were identified in the screening and confirmed in the validation cohort to be increased in sera of early-stage adenocarcinoma patients suffering from recurrence within 24 months. Elevated miRNA levels were exclusively observed in the group of high-risk patient diagnosed for operable adenocarcinoma compared with benign diagnosis or advanced tumour disease. The differentiation between pulmonary adenocarcinoma patients with low and high risk for recurrence was improved by accounting for both miR-142-3p levels and tumour stage (p=0.007; AUC=0.78). In conclusion, circulating miR-142-3p was found to be associated with a high risk of recurrence in early-stage lung adenocarcinoma patients, and a putative serum marker for risk assessment.
DOI:doi:10.1016/j.lungcan.2013.01.013
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.lungcan.2013.01.013
 Volltext: https://www.sciencedirect.com/science/article/pii/S0169500213000238
 DOI: https://doi.org/10.1016/j.lungcan.2013.01.013
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Circulating microRNAs
 Lung adenocarcinoma
 Prognostic markers
K10plus-PPN:1754028195
Verknüpfungen:→ Zeitschrift

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