| |  Online-Ressource |
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| Verfasst von: | Schlesiger, Magdalene [VerfasserIn]  |
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| | Ruff, Tobias [VerfasserIn] |
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| | MacLaren, Duncan Archibald Allan [VerfasserIn] |
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| | Barriuso-Ortega, Isabel [VerfasserIn] |
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| | Saidov, Khalid [VerfasserIn] |
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| | Yen, Ting-Yun [VerfasserIn] |
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| | Monyer, Hannah [VerfasserIn] |
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| Titel: | Two septal-entorhinal GABAergic projections differentially control coding properties of spatially tuned neurons in the medial entorhinal cortex |
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| Verf.angabe: | Magdalene Isabell Schlesiger, Tobias Ruff, Duncan Archibald Allan MacLaren, Isabel Barriuso-Ortega, Khalid Magomedovich Saidov, Ting-Yun Yen, and Hannah Monyer |
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| E-Jahr: | 2021 |
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| Jahr: | March 2, 2021 |
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| Umfang: | 21 S. |
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| Fussnoten: | Gesehen am 15.04.2021 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 34(2021,9) Art. 108801, Seite 1-15, e1-e6, 21 Seiten |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Septal parvalbumin-expressing (PV+) and calbindin-expressing (CB+) projections inhibit low-threshold and fast-spiking interneurons, respectively, in the medial entorhinal cortex (MEC). We investigate how the two inputs control neuronal activity in the MEC in freely moving mice. Stimulation of PV+ and CB+ terminals causes disinhibition of spatially tuned MEC neurons, but exerts differential effects on temporal coding and burst firing. Thus, recruitment of PV+ projections disrupts theta-rhythmic firing of MEC neurons, while stimulation of CB+ projections increases burst firing of grid cells and enhances phase precession in a cell-type-specific manner. Inactivation of septal PV+ or CB+ neurons differentially affects context, reference, and working memory. Together, our results reveal how specific connectivity of septal GABAergic projections with MEC interneurons translates into differential modulation of MEC neuronal coding. |
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| DOI: | doi:10.1016/j.celrep.2021.108801 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2021.108801 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124721001157 |
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| | DOI: https://doi.org/10.1016/j.celrep.2021.108801 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | burst firing |
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| | disinhibition |
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| | grid cells |
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| | interneurons |
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| | MEC, septum |
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| | medial entorhinal cortex |
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| | phase coding |
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| | phase precession |
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| | theta rhythm |
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| K10plus-PPN: | 1754796958 |
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| Verknüpfungen: | → Zeitschrift |
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Two septal-entorhinal GABAergic projections differentially control coding properties of spatially tuned neurons in the medial entorhinal cortex / Schlesiger, Magdalene [VerfasserIn]; March 2, 2021 (Online-Ressource)
