Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Sartorius, Ute [VerfasserIn]  |
| Krammer, Peter H. [VerfasserIn]  |
Titel: | Upregulation of bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines |
Verf.angabe: | Ute A. Sartorius and Peter H. Krammer |
Jahr: | 2002 |
Jahr des Originals: | 2001 |
Umfang: | 9 S. |
Teil: | volume:97 |
| year:2002 |
| number:5 |
| pages:584-592 |
| extent:9 |
Fussnoten: | First published: 01 November 2001 ; Gesehen am 14.04.2021 |
Titel Quelle: | Enthalten in: International journal of cancer |
Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
Jahr Quelle: | 2002 |
Band/Heft Quelle: | 97(2002), 5, Seite 584-592 |
ISSN Quelle: | 1097-0215 |
Abstract: | Chemotherapeutic drugs eliminate cancer cells by induction of apoptosis. Resistance to chemotherapy is partly due to a decreased apoptosis rate. Here we investigated resistance to anticancer drugs in 9 small cell lung cancer (SCLC) cell lines. Apoptosis was induced by cisplatin, doxorubicin and etoposide and was found to be independent of caspase-8 expression. Since caspase-8 is essential for signal transduction of death receptor-mediated apoptosis, all known death receptor systems are thus not required for drug-induced apoptosis in SCLC. Furthermore, we found that anticancer drugs could activate the mitochondrial pathway of apoptosis without involvement of upstream caspases. Finally, by culturing 3 sensitive cell lines in subtherapeutic concentrations of etoposide, resistant cells were generated that exhibit cross-resistance to cisplatin and doxorubicin. Drug resistance was paralleled by strong upregulation of Bcl-2, which diminished apoptosis by inhibiting the loss of the mitochondrial transmembrane potential and the release of cytochrome c. The role of bcl-2 in these processes was supported by bcl-2 transfection and antisense inhibition. These results indicate that Bcl-2 contributes to drug resistance in SCLC, a finding that has profound therapeutic implications. © 2001 Wiley-Liss, Inc. |
DOI: | doi:10.1002/ijc.10096 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/ijc.10096 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.10096 |
| DOI: https://doi.org/10.1002/ijc.10096 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | apoptosis |
| bcl-2 |
| chemotherapy |
| mitochondria |
| small cell lung cancer |
K10plus-PPN: | 175486998X |
Verknüpfungen: | → Zeitschrift |
Upregulation of bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines / Sartorius, Ute [VerfasserIn]; 2002 (Online-Ressource)
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