| |  Online-Ressource |
|---|
| Verfasst von: | Kosmala, Rebekka [VerfasserIn]  |
|---|
| | Fokas, Emmanouil [VerfasserIn] |
|---|
| | Flentje, Michael [VerfasserIn] |
|---|
| | Sauer, Rolf [VerfasserIn] |
|---|
| | Liersch, Torsten [VerfasserIn] |
|---|
| | Graeven, Ullrich [VerfasserIn] |
|---|
| | Fietkau, Rainer [VerfasserIn] |
|---|
| | Hohenberger, Werner [VerfasserIn] |
|---|
| | Arnold, Dirk [VerfasserIn] |
|---|
| | Hofheinz, Ralf-Dieter [VerfasserIn] |
|---|
| | Ghadimi, Michael [VerfasserIn] |
|---|
| | Ströbel, Philipp [VerfasserIn] |
|---|
| | Staib, Ludger [VerfasserIn] |
|---|
| | Grabenbauer, Gerhard G. [VerfasserIn] |
|---|
| | Folprecht, Gunnar [VerfasserIn] |
|---|
| | Kirste, Simon [VerfasserIn] |
|---|
| | Uter, Wolfgang [VerfasserIn] |
|---|
| | Gall, Christine [VerfasserIn] |
|---|
| | Rödel, Claus [VerfasserIn] |
|---|
| | Polat, Bülent [VerfasserIn] |
|---|
| Titel: | Quality of life in rectal cancer patients with or without oxaliplatin in the randomised CAO/ARO/AIO-04 phase 3 trial |
|---|
| Verf.angabe: | Rebekka Kosmala, Emmanouil Fokas, Michael Flentje, Rolf Sauer, Torsten Liersch, Ullrich Graeven, Rainer Fietkau, Werner Hohenberger, Dirk Arnold, Ralf-Dieter Hofheinz, Michael Ghadimi, Philipp Ströbel, Ludger Staib, Gerhard G. Grabenbauer, Gunnar Folprecht, Simon Kirste, Wolfgang Uter, Christine Gall, Claus Rödel, Bülent Polat |
|---|
| E-Jahr: | 2021 |
|---|
| Jahr: | February 2021 |
|---|
| Umfang: | 10 S. |
|---|
| Fussnoten: | Gesehen am 14.04.2021 |
|---|
| Titel Quelle: | Enthalten in: European journal of cancer |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1992 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 144(2021), Seite 281-290 |
|---|
| ISSN Quelle: | 1879-0852 |
|---|
| Abstract: | Background - The CAO/ARO/AIO trial has shown that oxaliplatin added to preoperative chemoradiotherapy and postoperative chemotherapy significantly improved disease-free survival in locally advanced rectal cancer (LARC). Here, we present a post-hoc analysis of quality of life (QoL) in disease-free patients. - Patients and methods - Between 2006 and 2010, 1236 patients with LARC were randomly assigned either to preoperative chemoradiotherapy followed by total mesorectal excision and postoperative chemotherapy (N = 623) or combined with oxaliplatin (N = 613). QoL questionnaires (EORTC QLQ-C30, colorectal module CR38) were completed at baseline, after postoperative chemotherapy and during follow-up. Analysis was performed according intent-to-treat. - Results - Available questionnaires (baseline) were 82% (N = 512) in the control and 84% (N = 513) in the investigational group. Response rates were 49% (533 of 1086) at 1 year and 43% (403 of 928) at 3 years. Global health status (GHS) for disease-free patients was stable in both groups (range 0-100). At baseline: standard arm 62.0 (mean, SD 21.6; N = 491) versus oxaliplatin arm 63.2 (mean, SD 22; N = 503); at 3 years: 69.4 (SD 19.3; N = 187) versus 65.4 (SD 22.2; N = 202). After treatment and at 3 years, no significant differences (≥10 points) between groups were found in QoL subscales. Disease-free patients experiencing neurotoxic side-effects (grade 1-4) showed reduced GHS at 3 years versus patients without neurotoxicity (mean 59.2 versus 69.3; P < 0.001), while grade 3-4 rate was low. - Conclusion - The addition of oxaliplatin was not associated with worse overall QoL. This information is of interest to patients in many ongoing rectal cancer trials. - Trial registration information - NCT00349076. |
|---|
| DOI: | doi:10.1016/j.ejca.2020.11.029 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ejca.2020.11.029 |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S0959804920313666 |
|---|
| | DOI: https://doi.org/10.1016/j.ejca.2020.11.029 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Chemoradiotherapy |
|---|
| | Oxaliplatin |
|---|
| | Quality of life |
|---|
| | Rectal neoplasms |
|---|
| K10plus-PPN: | 1754879624 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Quality of life in rectal cancer patients with or without oxaliplatin in the randomised CAO/ARO/AIO-04 phase 3 trial / Kosmala, Rebekka [VerfasserIn]; February 2021 (Online-Ressource)
