Blood cholesterol and outcome of patients with cancer under regular cardiological surveillance

• Verfasst von: Hohneck, Anna [VerfasserIn]
• Verfasst von: Rosenkaimer, Stephanie L. [VerfasserIn]
• Verfasst von: Hofheinz, Ralf-Dieter [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Verfasst von: Borggrefe, Martin [VerfasserIn]
• Verfasst von: Gerhards, Stefan [VerfasserIn]
• Titel: Blood cholesterol and outcome of patients with cancer under regular cardiological surveillance
• Verf.angabe: Anna Lena Hohneck, Stephanie Rosenkaimer, Ralf-Dieter Hofheinz, Ibrahim Akin, Martin Borggrefe, Stefan Gerhards
• E-Jahr: 2021
• Jahr: 12 February 2021
• Umfang: 10 S.
• Fussnoten: Gesehen am 15.04.2021
• Titel Quelle: Enthalten in: Current oncology
• Ort Quelle: Toronto, Ontario : Multimed, 2005
• Jahr Quelle: 2021
• Band/Heft Quelle: 28(2021), 1, Seite 863-872
• ISSN Quelle: 1718-7729
• DOI: doi:10.3390/curroncol28010085
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cancer related mortality
• Sach-SW: cardio-oncology
• Sach-SW: cholesterol
• K10plus-PPN: 1755000502

Abstract

Cardiovascular (CV) diseases and cancer share several similarities, including common risk factors. In the present investigation we assessed the relationship between cholesterol levels and mortality in a cardiooncological collective. In total, 551 patients receiving anticancer treatment were followed over a median of 41 (95% CI 40, 43) months and underwent regular cardiological surveillance. A total of 140 patients (25.4%) died during this period. Concomitant cardiac diseases were more common in patients who deceased (53 (37.9%) vs. 67 (16.3%), p < 0.0001), as well as prior stroke. There were no differences in the distribution of classical CV risk factors, such as hypertension, diabetes or nicotine consumption. While total cholesterol (mg/dL) was significantly lower in patients who deceased (157 ± 59 vs. 188 ± 53, p < 0.0001), both HDL and LDL cholesterol were not differing. In addition, cholesterol levels varied between different tumour entities; lowest levels were found in patients with tumours of the hepatopancreaticobiliary system (median 121 mg/dL), while patients with melanoma, cerebral tumours and breast cancer had rather high cholesterol levels (median > 190 mg/dL). Cholesterol levels were significantly lower in patients who died of cancer; lowest cholesterol levels were observed in patients who died of tumours with higher mitotic rate (mesenchymal tumours, cerebral tumours, breast cancer). Cox regression analysis revealed a significant mortality risk for patients with stem cell transplantation (HR 4.31) and metastasised tumour stages (HR 3.31), while cardiac risk factors were also associated with a worse outcome (known cardiac disease HR 1.58, prior stroke/TIA HR 1.73, total cholesterol HR 1.70), with the best discriminative performance found for total cholesterol (p = 0.002).