Iron metabolism in high-altitude residents

• Verfasst von: Muckenthaler, Martina [VerfasserIn]
• Verfasst von: Mairbäurl, Heimo [VerfasserIn]
• Verfasst von: Gassmann, Max [VerfasserIn]
• Titel: Iron metabolism in high-altitude residents
• Verf.angabe: Martina U. Muckenthaler, Heimo Mairbäurl, and Max Gassmann
• E-Jahr: 2020
• Jahr: 10 Oct 2020
• Umfang: 6 S.
• Fussnoten: Gesehen am 15.04.2021
• Titel Quelle: Enthalten in: Journal of applied physiology
• Ort Quelle: Bethesda, Md. : American Physiological Society, 1948
• Jahr Quelle: 2020
• Band/Heft Quelle: 129(2020), 4, Seite 920-925
• ISSN Quelle: 1522-1601
• DOI: doi:10.1152/japplphysiol.00019.2020
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1755001991

Abstract

Residents at high altitude cope with decreasing inspiratory oxygen partial pressure by stimulating erythropoiesis. The increase in hemoglobin levels requires high amounts of additional iron supplied from the diet. Here, we review available data on how iron metabolism adapts when living in a hypoxic environment. Our analysis reveals that long-term adaptation to high altitude enables healthy individuals to maintain their iron stores within the physiological range despite elevated requirements for erythropoiesis. However, in vulnerable populations with increased iron demand (e.g., pregnant women or exercising individuals), iron stores are less likely to be replenished quickly when living at high altitude. Future studies need to address whether different ethnicities have acquired genetic mechanisms to adapt to the elevated iron demand for erythropoiesis at high altitude.