| |  Online-Ressource |
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| Verfasst von: | Fic, Weronika [VerfasserIn]  |
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| | Bastock, Rebecca [VerfasserIn] |
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| | Raimondi, Francesco [VerfasserIn] |
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| | Los, Erinn [VerfasserIn] |
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| | Inoue, Yoshiko [VerfasserIn] |
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| | Gallop, Jennifer L. [VerfasserIn] |
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| | Russell, Robert B. [VerfasserIn] |
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| | St Johnston, Daniel [VerfasserIn] |
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| Titel: | RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion |
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| Verf.angabe: | Weronika Fic, Rebecca Bastock, Francesco Raimondi, Erinn Los, Yoshiko Inoue, Jennifer L. Gallop, Robert B. Russell, and Daniel St Johnston |
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| E-Jahr: | 2021 |
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| Jahr: | March 01 2021 |
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| Umfang: | 22 S. |
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| Teil: | volume:220 |
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| | year:2021 |
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| | number:4 |
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| | elocationid:e202009116 |
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| | pages:1-22 |
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| | extent:22 |
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| Fussnoten: | Gesehen am 20.07.2021 |
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| Titel Quelle: | Enthalten in: The journal of cell biology |
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| Ort Quelle: | New York, NY : Rockefeller Univ. Press, 1962 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 220(2021), 4, Artikel-ID e202009116, Seite 1-22 |
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| ISSN Quelle: | 1540-8140 |
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| Abstract: | Cdc42-GTP is required for apical domain formation in epithelial cells, where it recruits and activates the Par-6-aPKC polarity complex, but how the activity of Cdc42 itself is restricted apically is unclear. We used sequence analysis and 3D structural modeling to determine which Drosophila GTPase-activating proteins (GAPs) are likely to interact with Cdc42 and identified RhoGAP19D as the only high-probability Cdc42GAP required for polarity in the follicular epithelium. RhoGAP19D is recruited by α-catenin to lateral E-cadherin adhesion complexes, resulting in exclusion of active Cdc42 from the lateral domain. rhogap19d mutants therefore lead to lateral Cdc42 activity, which expands the apical domain through increased Par-6/aPKC activity and stimulates lateral contractility through the myosin light chain kinase, Genghis khan (MRCK). This causes buckling of the epithelium and invasion into the adjacent tissue, a phenotype resembling that of precancerous breast lesions. Thus, RhoGAP19D couples lateral cadherin adhesion to the apical localization of active Cdc42, thereby suppressing epithelial invasion. |
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| DOI: | doi:10.1083/jcb.202009116 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1083/jcb.202009116 |
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| | DOI: https://doi.org/10.1083/jcb.202009116 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1755003366 |
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| Verknüpfungen: | → Zeitschrift |
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RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion / Fic, Weronika [VerfasserIn]; March 01 2021 (Online-Ressource)
