Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Li-Weber, Min [VerfasserIn]  |
| Krammer, Peter H. [VerfasserIn]  |
Titel: | The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells |
Verf.angabe: | M. Li-Weber, M. Giaisi, S. Baumann, M.K. Treiber and P.H. Krammer |
E-Jahr: | 2002 |
Jahr: | 29 October 2002 |
Umfang: | 10 S. |
Teil: | volume:9 |
| year:2002 |
| number:11 |
| pages:1256-1265 |
| extent:10 |
Fussnoten: | Gesehen am 15.04.2021 |
Titel Quelle: | Enthalten in: Cell death and differentiation |
Ort Quelle: | Houndmills, Basingstoke : Nature Publishing Group, 1997 |
Jahr Quelle: | 2002 |
Band/Heft Quelle: | 9(2002), 11, Seite 1256-1265 |
ISSN Quelle: | 1476-5403 |
Abstract: | Apoptosis is a morphologically distinct form of cell death involved in many physiological and pathological processes. The death receptor CD95 (APO-1/Fas) and its ligand (L) CD95L are critically involved in activation-induced-cell-death (AICD) of activated T-cells. Here we show that the anti-inflammatory sesquiterpene lactone parthenolide derived from the European traditional herb-medicine feverfew and many Mexican India medicinal plants suppresses expression of the CD95L and CD95 at the mRNA levels, thus, preventing T-cells from AICD. We demonstrate that parthenolide blocks NF-κB binding to the two NF-κ binding sites of the CD95L promoter and suppresses promoter activity upon T-cell activation. Aberrant expression of CD95 and, particularly CD95L is dangerous and may lead to severe diseases. Our study indicates that parthenolide supports T-cell survival by down-regulating the CD95 system, at least in part, and, therefore, may have therapeutic potential as a new anti-apoptotic substance against AICD in T-cells. |
DOI: | doi:10.1038/sj.cdd.4401102 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.cdd.4401102 |
| Volltext: https://www.nature.com/articles/4401102 |
| DOI: https://doi.org/10.1038/sj.cdd.4401102 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1755013248 |
Verknüpfungen: | → Zeitschrift |
¬The¬ anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells / Li-Weber, Min [VerfasserIn]; 29 October 2002 (Online-Ressource)
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