The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells

• Verfasst von: Li-Weber, Min [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Titel: The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells
• Verf.angabe: M. Li-Weber, M. Giaisi, S. Baumann, M.K. Treiber and P.H. Krammer
• E-Jahr: 2002
• Jahr: 29 October 2002
• Umfang: 10 S.
• Teil: volume:9
• Teil: year:2002
• Teil: number:11
• Teil: pages:1256-1265
• Teil: extent:10
• Fussnoten: Gesehen am 15.04.2021
• Titel Quelle: Enthalten in: Cell death and differentiation
• Ort Quelle: Houndmills, Basingstoke : Nature Publishing Group, 1997
• Jahr Quelle: 2002
• Band/Heft Quelle: 9(2002), 11, Seite 1256-1265
• ISSN Quelle: 1476-5403
• DOI: doi:10.1038/sj.cdd.4401102
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1755013248

Abstract

Apoptosis is a morphologically distinct form of cell death involved in many physiological and pathological processes. The death receptor CD95 (APO-1/Fas) and its ligand (L) CD95L are critically involved in activation-induced-cell-death (AICD) of activated T-cells. Here we show that the anti-inflammatory sesquiterpene lactone parthenolide derived from the European traditional herb-medicine feverfew and many Mexican India medicinal plants suppresses expression of the CD95L and CD95 at the mRNA levels, thus, preventing T-cells from AICD. We demonstrate that parthenolide blocks NF-κB binding to the two NF-κ binding sites of the CD95L promoter and suppresses promoter activity upon T-cell activation. Aberrant expression of CD95 and, particularly CD95L is dangerous and may lead to severe diseases. Our study indicates that parthenolide supports T-cell survival by down-regulating the CD95 system, at least in part, and, therefore, may have therapeutic potential as a new anti-apoptotic substance against AICD in T-cells.