Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Kirchhoff, Sabine [VerfasserIn]  |
| Li-Weber, Min [VerfasserIn]  |
| Krammer, Peter H. [VerfasserIn]  |
Titel: | Viral IFN-Regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand Promoter |
Verf.angabe: | Sabine Kirchhoff, Thorsten Sebens, Sven Baumann, Andreas Krueger, Rainer Zawatzky, Min Li-Weber, Edgar Meinl, Frank Neipel, Bernhard Fleckenstein, and Peter H. Krammer |
E-Jahr: | 2002 |
Jahr: | February 1, 2002 |
Umfang: | 9 S. |
Teil: | volume:168 |
| year:2002 |
| number:3 |
| pages:1226-1234 |
| extent:9 |
Fussnoten: | Gesehen am 15.04.2021 |
Titel Quelle: | Enthalten in: The journal of immunology |
Ort Quelle: | Bethesda, Md. : Soc., 1916 |
Jahr Quelle: | 2002 |
Band/Heft Quelle: | 168(2002), 3, Seite 1226-1234 |
ISSN Quelle: | 1550-6606 |
Abstract: | The CD95 (also called APO-1/Fas) system plays a major role in the induction of apoptosis in lymphoid and nonlymphoid tissues. The CD95 ligand (CD95L) is induced in response to a variety of signals, including IFN-γ and TCR/CD3 stimulation. Here we report the identification of two positive regulatory IFN-regulatory factor-dependent domains (PRIDDs) in the CD95L promoter and its 5′ untranslated region, respectively. EMSAs demonstrate specific binding of IFN-γ-induced IFN-regulatory factor 1 (IRF-1) to the PRIDD sequences. Ectopic IRF-1 expression induces CD95L promoter activity. Furthermore, we demonstrate that PRIDDs play an important role in TCR/CD3-mediated CD95L induction. Most interestingly, viral IRFs of human herpes virus 8 (HHV8) totally abolish IRF-1-mediated and strongly reduce TCR/CD3-mediated CD95L induction. We demonstrate here for the first time that viral IRFs inhibit activation-induced cell death. Thus, these results demonstrate an important mechanism of HHV8 to modulate the immune response by down-regulation of CD95L expression. Inhibition of CD95-dependent T cell function might contribute to the immune escape of HHV8. |
DOI: | doi:10.4049/jimmunol.168.3.1226 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.4049/jimmunol.168.3.1226 |
| Volltext: https://www.jimmunol.org/content/168/3/1226 |
| DOI: https://doi.org/10.4049/jimmunol.168.3.1226 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1755014228 |
Verknüpfungen: | → Zeitschrift |
Viral IFN-Regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand Promoter / Kirchhoff, Sabine [VerfasserIn]; February 1, 2002 (Online-Ressource)
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