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Verfasst von:Nestle, Ursula [VerfasserIn]   i
 Nieder, C. [VerfasserIn]   i
 Walter, K. [VerfasserIn]   i
 Abel, Ulrich [VerfasserIn]   i
 Ukena, D. [VerfasserIn]   i
 Sybrecht, G. W. [VerfasserIn]   i
 Schnabel, K. [VerfasserIn]   i
Titel:A palliative accelerated irradiation regimen for advanced non-small-cell lung cancer vs. conventionally fractionated 60 GY
Titelzusatz:results of a randomized equivalence study
Verf.angabe:Ursula Nestle, Carsten Nieder, Karin Walter, Ulrich Abel, Dieter Ukena, Gerhard W. Sybrecht and Klaus Schnabel
Jahr:2000
Umfang:9 S.
Fussnoten:Gesehen am 16.04.2021
Titel Quelle:Enthalten in: International journal of radiation oncology, biology, physics
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1975
Jahr Quelle:2000
Band/Heft Quelle:48(2000), 1, Seite 95-103
ISSN Quelle:1879-355X
Abstract:PURPOSE: Radiation oncologists are often faced with patients with advanced non-small-cell lung cancer (NSCLC), who are not suitable candidates for state-of-the-art radical treatment, but who also are not judged to have a very short life expectancy. Some physicians treat these patients palliatively, whereas others advocate more intensive treatment. To find out if there is a substantial difference in outcome between these approaches, we performed a randomized prospective study. METHODS AND MATERIALS: Between 1994 and 1998, 152 eligible patients with advanced NSCLC Stage III (n = 121) or minimal Stage IV (n = 31) were randomized to receive conventionally fractionated (cf; A: 60 Gy, 6 weeks, n = 79) or short-term treatment (PAIR; B: 32 Gy, 2 Gy b.i.d.; n = 73) of tumor and mediastinum. RESULTS: One-year survival rate for all patients was 37% with no significant difference between the two treatment arms (A: 36%; B: 38%; p = 0.76). As far as can be judged from limited data available, palliation was adequate and similar for the two treatment arms. Apart from expected differences in the time course of esophagitis, acute side effects were moderate and equally distributed. No severe late effects were observed. CONCLUSIONS: In the present randomized trial, survival and available data on palliation were not different after cf to 60 Gy compared to the palliative PAIR regimen. Therefore, for patients who are not suitable for radical treatment approaches, the prescription of a palliative short-term irradiation appears preferable compared to cf over several weeks.
DOI:doi:10.1016/s0360-3016(00)00607-6
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/s0360-3016(00)00607-6
 DOI: https://doi.org/10.1016/s0360-3016(00)00607-6
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adenocarcinoma
 Adult
 Aged
 Aged, 80 and over
 Analysis of Variance
 Carcinoma, Non-Small-Cell Lung
 Carcinoma, Squamous Cell
 Dose Fractionation, Radiation
 Esophagitis
 Female
 Humans
 Karnofsky Performance Status
 Lung Neoplasms
 Male
 Middle Aged
 Neoplasm Staging
 Palliative Care
 Prospective Studies
 Radiation Pneumonitis
 Regression Analysis
 Survival Rate
 Time Factors
K10plus-PPN:1755138741
Verknüpfungen:→ Zeitschrift

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