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| Verfasst von: | Jia, Tianye [VerfasserIn]  |
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| | Xie, Chao [VerfasserIn] |
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| | Banaschewski, Tobias [VerfasserIn] |
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| | Barker, Gareth J. [VerfasserIn] |
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| | Bokde, Arun L. W. [VerfasserIn] |
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| | Büchel, Christian [VerfasserIn] |
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| | Quinlan, Erin Burke [VerfasserIn] |
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| | Desrivières, Sylvane [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Grigis, Antoine [VerfasserIn] |
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| | Garavan, Hugh [VerfasserIn] |
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| | Gowland, Penny [VerfasserIn] |
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| | Heinz, Andreas [VerfasserIn] |
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| | Ittermann, Bernd [VerfasserIn] |
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| | Martinot, Jean-Luc [VerfasserIn] |
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| | Martinot, Marie-Laure Paillère [VerfasserIn] |
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| | Nees, Frauke [VerfasserIn] |
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| | Orfanos, Dimitri Papadopoulos [VerfasserIn] |
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| | Poustka, Luise [VerfasserIn] |
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| | Fröhner, Juliane H. [VerfasserIn] |
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| | Smolka, Michael N. [VerfasserIn] |
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| | Walter, Henrik [VerfasserIn] |
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| | Whelan, Robert [VerfasserIn] |
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| | Schumann, Gunter [VerfasserIn] |
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| | Robbins, Trevor W. [VerfasserIn] |
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| | Feng, Jianfeng [VerfasserIn] |
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| Titel: | Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse |
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| Verf.angabe: | Tianye Jia, Chao Xie, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Trevor W. Robbins, Jianfeng Feng, Imagen Consortium |
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| E-Jahr: | 2021 |
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| Jahr: | 03 Feb 2021 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 19.04.2021 |
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| Titel Quelle: | Enthalten in: Science advances |
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| Ort Quelle: | Washington, DC [u.a.] : Assoc., 2015 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 7(2021), 6, Artikel-ID eabd4074, Seite 1-10 |
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| ISSN Quelle: | 2375-2548 |
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| Abstract: | Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was identified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence. - Neuroimaging data from 1890 adolescents implicated an orbitofronto-amygdalo-periaqueductal gray network in early alcohol abuse. - Neuroimaging data from 1890 adolescents implicated an orbitofronto-amygdalo-periaqueductal gray network in early alcohol abuse. |
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| DOI: | doi:10.1126/sciadv.abd4074 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1126/sciadv.abd4074 |
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| | Volltext: https://advances.sciencemag.org/content/7/6/eabd4074 |
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| | DOI: https://doi.org/10.1126/sciadv.abd4074 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1755363079 |
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| Verknüpfungen: | → Zeitschrift |
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Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse / Jia, Tianye [VerfasserIn]; 03 Feb 2021 (Online-Ressource)
