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| Verfasst von: | Jung, Erik [VerfasserIn]  |
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| | Osswald, Matthias [VerfasserIn] |
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| | Ratliff, Miriam [VerfasserIn] |
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| | Kardo, Helin [VerfasserIn] |
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| | Xie, Ruifan [VerfasserIn] |
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| | Heuer, Sophie [VerfasserIn] |
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| | Hoffmann, Dirk C. [VerfasserIn] |
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| | Kurz, Felix T. [VerfasserIn] |
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| | Keßler, Tobias [VerfasserIn] |
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| | Heiland, Sabine [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| | Sahm, Felix [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Winkler, Frank [VerfasserIn] |
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| Titel: | Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma |
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| Verf.angabe: | Erik Jung, Matthias Osswald, Miriam Ratliff, Helin Dogan, Ruifan Xie, Sophie Weil, Dirk C. Hoffmann, Felix T. Kurz, Tobias Kessler, Sabine Heiland, Andreas von Deimling, Felix Sahm, Wolfgang Wick and Frank Winkler |
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| E-Jahr: | 2021 |
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| Jahr: | 12 February 2021 |
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| Umfang: | 16 S. |
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| Fussnoten: | Gesehen am 19.04.2021 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 12(2021), Artikel-ID 1014, Seite 1-16 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Both the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have been associated with progression and resistance to therapies in glioblastoma, but their specific contribution remained unknown. By long-term tracking of tumor cell fate and dynamics in the live mouse brain, differential therapeutic responses in both niches are determined. Both the PVN, a preferential location of long-term quiescent glioma cells, and network integration facilitate resistance against cytotoxic effects of radiotherapy and chemotherapy—independently of each other, but with additive effects. Perivascular glioblastoma cells are particularly able to actively repair damage to tumor regions. Population of the PVN and resistance in it depend on proficient NOTCH1 expression. In turn, NOTCH1 downregulation induces resistant multicellular networks by TM extension. Our findings identify NOTCH1 as a central switch between the PVN and network niche in glioma, and demonstrate robust cross-compensation when only one niche is targeted. |
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| DOI: | doi:10.1038/s41467-021-21117-3 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1038/s41467-021-21117-3 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-021-21117-3 |
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| | DOI: https://doi.org/10.1038/s41467-021-21117-3 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1755371330 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma / Jung, Erik [VerfasserIn]; 12 February 2021 (Online-Ressource)
