IFN-γ represses IL-4 expression via IRF-1 and IRF-2

• Verfasst von: Elser, Bernd [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Verfasst von: Li-Weber, Min [VerfasserIn]
• Titel: IFN-γ represses IL-4 expression via IRF-1 and IRF-2
• Verf.angabe: Bernd Elser, Michael Lohoff, Sonja Kock, Marco Giaisi, Sabine Kirchhoff, Peter H. Krammer, and Min Li-Weber
• E-Jahr: 2002
• Jahr: 16 December 2002
• Umfang: 10 S.
• Teil: volume:17
• Teil: year:2002
• Teil: number:6
• Teil: month:12
• Teil: pages:703-712
• Teil: extent:10
• Fussnoten: Gesehen am 20.04.2021
• Titel Quelle: Enthalten in: Immunity
• Ort Quelle: [Cambridge, Mass.] : Cell Press, 1994
• Jahr Quelle: 2002
• Band/Heft Quelle: 17(2002), 6 vom: Dez., Seite 703-712
• ISSN Quelle: 1097-4180
• DOI: doi:10.1016/S1074-7613(02)00471-5
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1755410530

Abstract

Polarization of CD4+ T helper cells toward either a Th1 or Th2 response can significantly influence host immunity to pathogens. IL-4 and IFN-γ are the signature cytokines of Th2 and Th1 cells, respectively. IFN-γ was shown to assist Th1 development by promoting IL-12 and IL-12 receptor expression. So far, direct influence of Th2 cytokine expression by IFN-γ has not been described. We show here that IFN-γ directly suppresses IL-4 gene expression. IRF-1 and IRF-2 induced by IFN-γ bind to three distinct IL-4 promoter sites and function as transcriptional repressors. Our data demonstrate a direct negative feedback of IFN-γ on expression of the Th2 cytokine gene IL-4 and, thus, provide evidence for another important mechanism by which IFNγ assists Th1 and attenuates Th2 responses.