Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Skopp, Gisela [VerfasserIn]   i
 Pötsch-Schneider, Lucia Edeltraud [VerfasserIn]   i
 Mattern, Rainer [VerfasserIn]   i
 Aderjan, Rolf [VerfasserIn]   i
Titel:Short-term stability of lysergic acid diethylamide (LSD), N-desmethyl-LSD, and 2-oxo-3-hydroxy-LSD in urine, assessed by liquid chromatography-tandem mass spectrometry
Verf.angabe:Gisela Skopp, Lucia Pötsch, Rainer Mattern, Rolf Aderjan
E-Jahr:2002
Jahr:01 September 2002
Umfang:4 S.
Teil:volume:48
 year:2002
 number:9
 pages:1615-1618
 extent:4
Fussnoten:Gesehen am 21.04.2021
Titel Quelle:Enthalten in: Clinical chemistry
Ort Quelle:Washington, DC : American Association for Clinical Chemistry, 1955
Jahr Quelle:2002
Band/Heft Quelle:48(2002), 9, Seite 1615-1618
ISSN Quelle:1530-8561
Abstract:Lysergic acid diethylamide (LSD) is one of the most potent hallucinogenic agents known. Recently, data on emergency department episodes related to the use of drugs commonly thought as “club drugs” have also included LSD (1). Confirmation of LSD use by testing biological fluids is still an analytical challenge because of its extensive, rapid metabolism and its instability (2)(3)(4). After ingestion of a typical street dose (40-120 μg), the concentration of LSD in urine falls to <1 μg/L within a few hours (2)(5)(6). Recently, N-desmethyl-LSD (nor-LSD) and 2-oxo-3-hydroxy-LSD (O-H-LSD) have been identified as LSD metabolites in human urine (7)(8). Measured nor-LSD concentrations were reported to be in the same concentration range as LSD, whereas the measured concentrations of O-H-LSD were severalfold higher (0.02-21.4 μg/L) (7)(9)(10)(11). The application of liquid chromatography-tandem mass spectrometry (LC-MS/MS) improved the detection of LSD use (9)(10)(12)(13)(14)(15); the method is also less susceptible to interferences when used for drug screening (16)(17). In a few studies, O-H-LSD and nor-LSD have also been measured (6)(7)(8)(10)(12)(13)(14)(15). LSD has been shown to rapidly decompose in urine samples exposed to an increased temperature or to sunlight or ultraviolet light (18)(19)(20)(21), but stability data on major LSD metabolites are not yet available.
DOI:doi:10.1093/clinchem/48.9.1615
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1093/clinchem/48.9.1615
 Volltext: https://academic.oup.com/clinchem/article/48/9/1615/5642366
 DOI: https://doi.org/10.1093/clinchem/48.9.1615
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1755603126
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68726202   QR-Code
zum Seitenanfang