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Verfasst von:Bürger, Friederike [VerfasserIn]   i
 Krieg, Peter [VerfasserIn]   i
 Schurich, Bärbel [VerfasserIn]   i
 Marks, Friedrich [VerfasserIn]   i
 Fürstenberger, Gerhard [VerfasserIn]   i
Titel:Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes
Verf.angabe:Friederike Bürger, Peter Krieg, Andreas Kinzig, Bärbel Schurich, Friedrich Marks, and Gerhard Fürstenberger
E-Jahr:1999
Jahr:12 March 1999
Umfang:10 S.
Teil:volume:24
 year:1999
 number:2
 pages:108-117
 extent:10
Fussnoten:Gesehen am 21.04.2021
Titel Quelle:Enthalten in: Molecular carcinogenesis
Ort Quelle:New York, NY : Wiley Interscience, 1988
Jahr Quelle:1999
Band/Heft Quelle:24(1999), 2, Seite 108-117
ISSN Quelle:1098-2744
Abstract:The expression pattern, enzymatic activity, and products of 8-lipoxygenase (LOX) were analyzed in normal and neoplastic skin of NMRI mice. While barely detectable in normal epidermis, 8-LOX was transiently induced by 12-O-tetradecanoylphorbol-13-acetate and constitutively expressed in papillomas but not carcinomas obtained by the initiation-promotion protocol of mouse skin carcinogenesis. The product profile and chirality of both the native and the recombinant protein produced the S enantiomers of 8-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid (8-HETE) and 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE) as the main arachidonic acid- and linoleic acid-derived metabolites. As compared with normal epidermis, papillomas exhibited 25- and 4-fold elevated levels of 8-HETE and 9-HODE, respectively. However, the varying S to R ratios of 8-HETE and the predominance of 9(R)-HODE indicated that in addition to 8(S)-LOX, other enzymes yet to be defined may be involved in 8-HETE and 9-HODE production. The massive accumulation of both 8-HETE and 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE) point to a critical role of these LOX pathways in epidermal tumor development, in particular in the papilloma stage. Here we showed that 8- and 12-hydroperoxyeicosatetraenoic acids and 8- and 12-HETE induce chromosomal alterations in cycling primary basal keratinocytes. Mol. Carcinog. 24:108-117, 1999. © 1999 Wiley-Liss, Inc.
DOI:doi:10.1002/(SICI)1098-2744(199902)24:2<108::AID-MC5>3.0.CO;2-R
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Volltext ; Verlag: https://doi.org/https://doi.org/10.1002/(SICI)1098-2744(199902)24:2<108::AID-MC5>3.0.CO;2-R
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291098-2744%28199902%2924%3A2%3C108%3A%3AAID-MC5%3E3.0.CO%3B2-R
 DOI: https://doi.org/10.1002/(SICI)1098-2744(199902)24:2<108::AID-MC5>3.0.CO;2-R
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:8-lipoxygenase
 clastogenic effects
 keratinocytes
 multistage mouse skin carcinogenesis
K10plus-PPN:1755608527
Verknüpfungen:→ Zeitschrift

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