| Online-Ressource |
Verfasst von: | Bürger, Friederike [VerfasserIn]  |
| Krieg, Peter [VerfasserIn]  |
| Schurich, Bärbel [VerfasserIn]  |
| Marks, Friedrich [VerfasserIn]  |
| Fürstenberger, Gerhard [VerfasserIn]  |
Titel: | Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes |
Verf.angabe: | Friederike Bürger, Peter Krieg, Andreas Kinzig, Bärbel Schurich, Friedrich Marks, and Gerhard Fürstenberger |
E-Jahr: | 1999 |
Jahr: | 12 March 1999 |
Umfang: | 10 S. |
Teil: | volume:24 |
| year:1999 |
| number:2 |
| pages:108-117 |
| extent:10 |
Fussnoten: | Gesehen am 21.04.2021 |
Titel Quelle: | Enthalten in: Molecular carcinogenesis |
Ort Quelle: | New York, NY : Wiley Interscience, 1988 |
Jahr Quelle: | 1999 |
Band/Heft Quelle: | 24(1999), 2, Seite 108-117 |
ISSN Quelle: | 1098-2744 |
Abstract: | The expression pattern, enzymatic activity, and products of 8-lipoxygenase (LOX) were analyzed in normal and neoplastic skin of NMRI mice. While barely detectable in normal epidermis, 8-LOX was transiently induced by 12-O-tetradecanoylphorbol-13-acetate and constitutively expressed in papillomas but not carcinomas obtained by the initiation-promotion protocol of mouse skin carcinogenesis. The product profile and chirality of both the native and the recombinant protein produced the S enantiomers of 8-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid (8-HETE) and 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE) as the main arachidonic acid- and linoleic acid-derived metabolites. As compared with normal epidermis, papillomas exhibited 25- and 4-fold elevated levels of 8-HETE and 9-HODE, respectively. However, the varying S to R ratios of 8-HETE and the predominance of 9(R)-HODE indicated that in addition to 8(S)-LOX, other enzymes yet to be defined may be involved in 8-HETE and 9-HODE production. The massive accumulation of both 8-HETE and 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE) point to a critical role of these LOX pathways in epidermal tumor development, in particular in the papilloma stage. Here we showed that 8- and 12-hydroperoxyeicosatetraenoic acids and 8- and 12-HETE induce chromosomal alterations in cycling primary basal keratinocytes. Mol. Carcinog. 24:108-117, 1999. © 1999 Wiley-Liss, Inc. |
DOI: | doi:10.1002/(SICI)1098-2744(199902)24:2<108::AID-MC5>3.0.CO;2-R |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/https://doi.org/10.1002/(SICI)1098-2744(199902)24:2<108::AID-MC5>3.0.CO;2-R |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291098-2744%28199902%2924%3A2%3C108%3A%3AAID-MC5%3E3.0.CO%3B2-R |
| DOI: https://doi.org/10.1002/(SICI)1098-2744(199902)24:2<108::AID-MC5>3.0.CO;2-R |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | 8-lipoxygenase |
| clastogenic effects |
| keratinocytes |
| multistage mouse skin carcinogenesis |
K10plus-PPN: | 1755608527 |
Verknüpfungen: | → Zeitschrift |
Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes / Bürger, Friederike [VerfasserIn]; 12 March 1999 (Online-Ressource)