Status: Bibliographieeintrag
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| Verfasst von: | Münkel, Christian [VerfasserIn]  |
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| | Eils, Roland [VerfasserIn] |
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| | Langowski, Jörg [VerfasserIn] |
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| Titel: | Compartmentalization of interphase chromosomes observed in simulation and experiment |
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| Verf.angabe: | Christian Münkel, Roland Eils, Steffen Dietzel, Daniele Zink, Carsten Mehring, Gero Wedemann, Thomas Cremer and Jörg Langowski |
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| E-Jahr: | 2002 |
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| Jahr: | 25 May 2002 |
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| Jahr des Originals: | 1999 |
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| Umfang: | 13 S. |
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| Teil: | volume:285 |
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| | year:1999 |
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| | number:3 |
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| | pages:1053-1065 |
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| | extent:13 |
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| Fussnoten: | Elektronische Reproduktion der Druckausgabe ; Gesehen am 23.04.2021 |
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| Titel Quelle: | Enthalten in: Journal of molecular biology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1959 |
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| Jahr Quelle: | 1999 |
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| Band/Heft Quelle: | 285(1999), 3, Seite 1053-1065 |
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| ISSN Quelle: | 1089-8638 |
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| Abstract: | Human interphase chromosomes were simulated as a flexible fiber with excluded volume interaction, which represents the chromatin fiber of each chromosome. For the higher-order structures, we assumed a folding into 120kb loops and an arrangement of these loops into rosette-like subcompartments. Chromosomes consist of subcompartments connected by small fragments of chromatin. Number and size of subcompartments correspond with chromosome bands in early prophase. We observed essentially separated chromosome arms in both our model calculations and confocal laser scanning microscopy, and measured the same overlap in simulation and experiment. Overlap, number and size of chromosome 15 subcompartments of our model chromosomes agree with subchromosomal foci composed of either early or late replicating chromatin, which were observed at all stages of the cell cycle and possibly provide a functionally relevant unit of chromosome territory compartmentalization. Computed distances of chromosome specific markers both onMb and 10-100Mb scale agree with fluorescent in situ hybridization measurements under different preparation conditions. |
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| DOI: | doi:10.1006/jmbi.1998.2361 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1006/jmbi.1998.2361 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0022283698923610 |
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| | DOI: https://doi.org/10.1006/jmbi.1998.2361 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | higher order chromatin structure |
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| | interphase chromosomes |
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| | Monte Carlo |
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| | nuclear organization |
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| | polymers |
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| K10plus-PPN: | 1755827105 |
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| Verknüpfungen: | → Zeitschrift |
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Compartmentalization of interphase chromosomes observed in simulation and experiment / Münkel, Christian [VerfasserIn]; 25 May 2002 (Online-Ressource)
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