Cervical cancer cells induce apoptosis of cytotoxic T lymphocytes

• Verfasst von: Contreras, Diana [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Titel: Cervical cancer cells induce apoptosis of cytotoxic T lymphocytes
• Verf.angabe: Diana N. Contreras, Peter H. Krammer, Ronald K. Potkul, Ping Bu, Juan L. Rossi, Andreas M. Kaufmann, Lutz Gissmann, Liang Qiao
• E-Jahr: 2000
• Jahr: January 2000
• Umfang: 8 S.
• Teil: volume:23
• Teil: year:2000
• Teil: number:1
• Teil: pages:67-74
• Teil: extent:8
• Fussnoten: Gesehen am 26.04.2021
• Titel Quelle: Enthalten in: Journal of immunotherapy
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1991
• Jahr Quelle: 2000
• Band/Heft Quelle: 23(2000), 1, Seite 67-74
• ISSN Quelle: 1537-4513
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1755910827

Abstract

The goal of immunotherapy is to eliminate tumors by generating tumor-specific cytotoxic T lymphocytes (CTLs) in patients or by adoptively transferring ex vivo-activated CTLs into patients. Clinical trials have shown that tumor-specific CTLs often disappear before tumors are completely eliminated. In this study, the authors show that CTLs specific for cervical tumor cells undergo apoptosis after they are co-cultured with cervical tumor cells. The established cervical tumor cell lines and cervical cancer tissues express CD95 (Fas/Apo-1) ligand. The tumor cell-induced T-cell apoptosis can be blocked by an inhibitory anti-CD95 (APO-1/Fas) antibody, indicating that tumor cells induce apoptosis of CTLs through CD95-CD95 ligand interaction. Addition of interleukin-2 (IL-2) and IL-7 into the culture rescues the CTL from tumor cell-induced apoptosis. The rescued T cells retain their full antitumor cytotoxicity. These data suggest that human cervical tumor cells might actively downregulate a cellular immune response by inducing apoptosis of specific T cells during immunotherapy. Local use of IL-2 and IL-7 as adjuvants may promote survival of the CTL and, thus, enhance the efficacy of immunotherapy.