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Verfasst von:Abel, Ulrich [VerfasserIn]   i
 Koch, Armin [VerfasserIn]   i
Titel:The role of randomization in clinical studies
Titelzusatz:myths and beliefs
Verf.angabe:Ulrich Abel and Armin Koch
Jahr:1999
Umfang:11 S.
Fussnoten:Gesehen am 26.04.2021
Titel Quelle:Enthalten in: Journal of clinical epidemiology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1988
Jahr Quelle:1999
Band/Heft Quelle:52(1999), 6, Seite 487-497
ISSN Quelle:1878-5921
Abstract:On the basis of a survey of the methodological literature, we analyze widespread views on randomization and the advantage of randomized over nonrandomized studies. These views follow from theoretical considerations and at least three types of empirical investigations into the results of published studies. Randomization is often credited with advantages that it does not possess or confer. Several popular theoretical arguments in favor of randomization are shown to be either incorrect or imprecise. The published empirical comparisons of randomized with nonrandomized studies have methodological weaknesses and do not give any convincing information about the value of carefully designed and conducted nonrandomized studies. Six arguments, most of which are pragmatic rather than epistemological, are given to support our belief that randomization should not be avoided without compelling need. We conclude that although there are good arguments in favor of randomization, these are not the ones usually found in the literature. The very negative view on nonrandomized studies sometimes encountered in biostatistics and medicine may be comprehensible from a historical, pragmatic, or educational viewpoint, but it is not well founded on epistemological grounds.
DOI:doi:10.1016/s0895-4356(99)00041-4
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/s0895-4356(99)00041-4
 Volltext: https://linkinghub.elsevier.com/retrieve/pii/S0895435699000414
 DOI: https://doi.org/10.1016/s0895-4356(99)00041-4
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Causality
 Epidemiologic Studies
 Humans
 Random Allocation
 Randomized Controlled Trials as Topic
K10plus-PPN:175592402X
Verknüpfungen:→ Zeitschrift

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