Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Kirchhoff, Sabine [VerfasserIn]  |
| Li-Weber, Min [VerfasserIn]  |
| Krammer, Peter H. [VerfasserIn]  |
Titel: | Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells |
Verf.angabe: | Sabine Kirchhoff, Wolfgang W. Müller, Min Li‐Weber and Peter H. Krammer |
E-Jahr: | 2000 |
Jahr: | 29 November 2000 |
Umfang: | 10 S. |
Teil: | volume:30 |
| year:2000 |
| number:10 |
| pages:2765-2774 |
| extent:10 |
Fussnoten: | Gesehen am 26.04.2021 ; Im Titel ist der Ausdruck "short" tiefgestellt |
Titel Quelle: | Enthalten in: European journal of immunology |
Ort Quelle: | Weinheim : Wiley-VCH, 1971 |
Jahr Quelle: | 2000 |
Band/Heft Quelle: | 30(2000), 10, Seite 2765-2774 |
ISSN Quelle: | 1521-4141 |
Abstract: | Efficient activation of antigen-specific T cells requires co-stimulatory signals provided e.g. by CD28. Re-exposure to antigen and CD28 co-stimulation reduces activation-induced cell death (AICD) and increases the number of T cells performing effector functions. AICD is mediated predominantly by CD95 (APO-1/Fas) and its cognate ligand (CD95L). In an in vitro model system, using human peripheral activated T cells, we demonstrate here that co-stimulation prevents CD95L expression. Moreover, we show that co-stimulation reduces the activity of the CD95 death-inducing signaling complex and procaspase-8 activation. In parallel, co-stimulation strongly increases expression of the short form of the FLICE-inhibitory protein c-FLIPshort and of Bcl-xL. These data provide important new insight into the molecular mechanisms of apoptosis resistance in co-stimulated T cells. |
DOI: | doi:10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/https://doi.org/10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/1521-4141%28200010%2930%3A10%3C2765%3A%3AAID-IMMU2765%3E3.0.CO%3B2-W |
| DOI: https://doi.org/10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Activation-induced cell death |
| CD95 (APO-1/Fas) |
| Co-stimulation |
| FLICE-inhibitory protein |
| T cell |
K10plus-PPN: | 1755936206 |
Verknüpfungen: | → Zeitschrift |
Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells / Kirchhoff, Sabine [VerfasserIn]; 29 November 2000 (Online-Ressource)
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