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Verfasst von:Jarolimek, Wolfgang [VerfasserIn]   i
 Bäurle, Jörg [VerfasserIn]   i
 Misgeld, Ulrich [VerfasserIn]   i
Titel:Pore mutation in a G-protein-gated inwardly rectifying K+ channel subunit causes loss of K+-dependent inhibition in weaver hippocampus
Verf.angabe:Wolfgang Jarolimek, Jörg Bäurle and Ulrich Misgeld
E-Jahr:1998
Jahr:1 June 1998
Umfang:7 S.
Teil:volume:18
 year:1998
 number:11
 pages:4001-4007
 extent:7
Fussnoten:Im Text sind "+" hochgestellt ; Gesehen am 27.04.2021
Titel Quelle:Enthalten in: The journal of neuroscience
Ort Quelle:Washington, DC : Soc., 1981
Jahr Quelle:1998
Band/Heft Quelle:18(1998), 11, Seite 4001-4007
ISSN Quelle:1529-2401
Abstract:Weaver (wv) mice carry a point mutation in the pore region of a G-protein-gated inwardly rectifying K+ channel subunit (Kir3.2). wvKir3.2 conducts inward currents that may cause the loss of neurons in the cerebellum and substantia nigra. Although Kir3.2 is widely expressed in the CNS, significant morphological or physiological changes have not been reported for other brain areas. We studied the role ofwvKir3.2 in hippocampal slices of young [postnatal day (P) 4-18] and adult wv/wv (≥P24) mice, because protein levels of Kir 3.1 and Kir3.2 appear to be normal in the first 3 postnatal weeks and only decrease thereafter. In disinhibited slices, the GABAB receptor agonist R-baclofen reduced burst activity in wv/wv mice but was much more potent in wild-type mice. Mean resting membrane potential, slope input resistance, and membrane time constant of CA3 neurons of adultwv/wv and wild-type mice were indistinguishable. However, R-baclofen or chloroadenosine did not induce K+ currents or any other conductance change inwv/wv mice. Moreover, electrical or chemical stimulation of inhibitory neurons did not evoke slow IPSPs in adultwv/wv mice. Only in a few cells of youngwv/wv mice did GABAB receptor activation byR-baclofen or presynaptic stimulation induce small inward currents, which were likely caused by a Na+ion influx through wvKir3.2 channels. The data show that the pore mutation in wvKir3.2 channels results in a hippocampal phenotype resembling Kir3.2-deficient mutants, although it is not associated with the occurrence of seizures.
DOI:doi:10.1523/JNEUROSCI.18-11-04001.1998
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1523/JNEUROSCI.18-11-04001.1998
 Volltext: https://www.jneurosci.org/content/18/11/4001
 DOI: https://doi.org/10.1523/JNEUROSCI.18-11-04001.1998
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:adenosine
 G-protein-activated potassium currents
 GABAB receptors
 GIRK2
 hippocampus
 Kir3.2
 R-baclofen
 serotonin
 slow IPSPs
 weaver
K10plus-PPN:1755975767
Verknüpfungen:→ Zeitschrift

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