Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Jarolimek, Wolfgang [VerfasserIn]  |
| Bäurle, Jörg [VerfasserIn]  |
| Misgeld, Ulrich [VerfasserIn]  |
Titel: | Impaired inhibition of epileptiform activity by baclofen, but not by adenosine in the weaver hippocampus |
Verf.angabe: | Wolfgang Jarolimek, Jörg Bäurle, Ulrich Misgeld |
Jahr: | 2000 |
Umfang: | 8 S. |
Teil: | volume:39 |
| year:2000 |
| number:2 |
| pages:246-253 |
| extent:8 |
Fussnoten: | Online 27 December 1999 ; Gesehen am 27.04.2021 |
Titel Quelle: | Enthalten in: Neuropharmacology |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1970 |
Jahr Quelle: | 2000 |
Band/Heft Quelle: | 39(2000), 2, Seite 246-253 |
ISSN Quelle: | 1873-7064 |
Abstract: | The weaver defect results in a loss of baclofen- and adenosine-gated K+ conductance in the hippocampus of adult homozygous (wv/wv) mice. In addition, suppression of hippocampal epileptiform activity by baclofen is impaired (Jarolimek, W., Bäurle, J., Misgeld, U., 1998. Pore mutation in a G protein-gated inwardly rectifying K+ channel subunit causes loss of K+ dependent inhibition in weaver hippocampus. Journal of Neuroscience 18, 4001-4007). We used wv/wv and wild-type (+/+) mice to determine whether K+ conductance increases are essential for the suppression of epileptiform activity by R-baclofen and adenosine in disinhibited hippocampal slices. In wv/wv mice R-baclofen was less potent by two orders of magnitude in reducing the frequency of spontaneous synchronous burst discharges than in +/+ mice. Endogenous adenosine and adenosine A1 receptor agonists differed only slightly in their efficacy to inhibit spontaneous synchronous burst discharges in wv/wv and +/+ mice. The findings on adenosine A1 receptors suggest that the varied efficacy of R-baclofen in wv/wv and +/+ mice may not be explained solely on the basis of a loss of ligand-gated K+ conductance. Therefore, we investigated the affinity of GABAB receptors for the antagonist CGP55845A in wv/wv and +/+ hippocampi. Schild plot analysis revealed a KD for the GABAB antagonist CGP55845A 10 fold higher in wv/wv than in +/+ mice. The data suggest that an alteration of GABAB receptors could contribute to the reduced efficacy of R-baclofen to suppress hippocampal epileptiform activity in weaver mice, while the suppression by adenosine remains largely unaffected. |
DOI: | doi:10.1016/S0028-3908(99)00089-1 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/S0028-3908(99)00089-1 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0028390899000891 |
| DOI: https://doi.org/10.1016/S0028-3908(99)00089-1 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | -baclofen |
| Adenosine |
| G protein-activated potassium currents |
| GABA receptors |
| Kir3.2 |
K10plus-PPN: | 1755985371 |
Verknüpfungen: | → Zeitschrift |
Impaired inhibition of epileptiform activity by baclofen, but not by adenosine in the weaver hippocampus / Jarolimek, Wolfgang [VerfasserIn]; 2000 (Online-Ressource)
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