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Verfasst von:Jarolimek, Wolfgang [VerfasserIn]   i
 Bäurle, Jörg [VerfasserIn]   i
 Misgeld, Ulrich [VerfasserIn]   i
Titel:Impaired inhibition of epileptiform activity by baclofen, but not by adenosine in the weaver hippocampus
Verf.angabe:Wolfgang Jarolimek, Jörg Bäurle, Ulrich Misgeld
Jahr:2000
Umfang:8 S.
Teil:volume:39
 year:2000
 number:2
 pages:246-253
 extent:8
Fussnoten:Online 27 December 1999 ; Gesehen am 27.04.2021
Titel Quelle:Enthalten in: Neuropharmacology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1970
Jahr Quelle:2000
Band/Heft Quelle:39(2000), 2, Seite 246-253
ISSN Quelle:1873-7064
Abstract:The weaver defect results in a loss of baclofen- and adenosine-gated K+ conductance in the hippocampus of adult homozygous (wv/wv) mice. In addition, suppression of hippocampal epileptiform activity by baclofen is impaired (Jarolimek, W., Bäurle, J., Misgeld, U., 1998. Pore mutation in a G protein-gated inwardly rectifying K+ channel subunit causes loss of K+ dependent inhibition in weaver hippocampus. Journal of Neuroscience 18, 4001-4007). We used wv/wv and wild-type (+/+) mice to determine whether K+ conductance increases are essential for the suppression of epileptiform activity by R-baclofen and adenosine in disinhibited hippocampal slices. In wv/wv mice R-baclofen was less potent by two orders of magnitude in reducing the frequency of spontaneous synchronous burst discharges than in +/+ mice. Endogenous adenosine and adenosine A1 receptor agonists differed only slightly in their efficacy to inhibit spontaneous synchronous burst discharges in wv/wv and +/+ mice. The findings on adenosine A1 receptors suggest that the varied efficacy of R-baclofen in wv/wv and +/+ mice may not be explained solely on the basis of a loss of ligand-gated K+ conductance. Therefore, we investigated the affinity of GABAB receptors for the antagonist CGP55845A in wv/wv and +/+ hippocampi. Schild plot analysis revealed a KD for the GABAB antagonist CGP55845A 10 fold higher in wv/wv than in +/+ mice. The data suggest that an alteration of GABAB receptors could contribute to the reduced efficacy of R-baclofen to suppress hippocampal epileptiform activity in weaver mice, while the suppression by adenosine remains largely unaffected.
DOI:doi:10.1016/S0028-3908(99)00089-1
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/S0028-3908(99)00089-1
 Volltext: https://www.sciencedirect.com/science/article/pii/S0028390899000891
 DOI: https://doi.org/10.1016/S0028-3908(99)00089-1
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:-baclofen
 Adenosine
 G protein-activated potassium currents
 GABA receptors
 Kir3.2
K10plus-PPN:1755985371
Verknüpfungen:→ Zeitschrift

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