Status: Bibliographieeintrag
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| Verfasst von: | Kelsch, Wolfgang [VerfasserIn]  |
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| | Hormuzdi, Sheriar [VerfasserIn] |
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| | Straube, Emine [VerfasserIn] |
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| | Lewen, Andrea [VerfasserIn] |
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| | Monyer, Hannah [VerfasserIn] |
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| | Misgeld, Ulrich [VerfasserIn] |
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| Titel: | Insulin-like growth factor 1 and a cytosolic tyrosine kinase activate chloride outward transport during maturation of hippocampal neurons |
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| Verf.angabe: | Wolfgang Kelsch, Sheriar Hormuzdi, Emine Straube, Andrea Lewen, Hannah Monyer, and Ulrich Misgeld |
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| E-Jahr: | 2001 |
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| Jahr: | November 1, 2001 |
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| Umfang: | 9 S. |
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| Teil: | volume:21 |
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| | year:2001 |
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| | number:21 |
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| | pages:8339-8347 |
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| | extent:9 |
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| Fussnoten: | Gesehen am 27.04.2021 |
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| Titel Quelle: | Enthalten in: The journal of neuroscience |
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| Ort Quelle: | Washington, DC : Soc., 1981 |
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| Jahr Quelle: | 2001 |
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| Band/Heft Quelle: | 21(2001), 21, Seite 8339-8347 |
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| ISSN Quelle: | 1529-2401 |
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| Abstract: | The development of hyperpolarizing inhibition is an important step in the maturation of neuronal networks. Hyperpolarizing inhibition requires Cl− outward transport that is accomplished by KCC2, a K+/Cl− cotransporter. We show that cultured hippocampal neurons initially contain an inactive form of the KCC2 protein, which becomes activated during subsequent maturation of the neurons. We also show that this process is accelerated by transient stimulation of IGF-1 receptors. Because the transporter can be rapidly activated by coapplication of IGF-1 and an Src kinase and can be deactivated by membrane-permeable protein tyrosine kinase inhibitors, we suggest that activation of K+/Cl− cotransporter function by endogenous protein tyrosine kinases mediates the developmental switch of GABAergic responses to hyperpolarizing inhibition. |
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| DOI: | doi:10.1523/JNEUROSCI.21-21-08339.2001 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1523/JNEUROSCI.21-21-08339.2001 |
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| | Volltext: https://www.jneurosci.org/content/21/21/8339 |
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| | DOI: https://doi.org/10.1523/JNEUROSCI.21-21-08339.2001 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | development |
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| | furosemide |
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| | GABAA |
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| | genistein |
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| | hippocampus |
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| | IGF-1 |
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| | KCC2 |
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| | tyrosine kinase |
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| K10plus-PPN: | 1755998694 |
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| Verknüpfungen: | → Zeitschrift |
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Insulin-like growth factor 1 and a cytosolic tyrosine kinase activate chloride outward transport during maturation of hippocampal neurons / Kelsch, Wolfgang [VerfasserIn]; November 1, 2001 (Online-Ressource)
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