| |  Online-Ressource |
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| Verfasst von: | Strosche, Alicia [VerfasserIn]  |
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| | Zhang, Xiaochu [VerfasserIn] |
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| | Kirsch, Martina [VerfasserIn] |
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| | Hermann, Derik [VerfasserIn] |
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| | Ende, Gabriele [VerfasserIn] |
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| | Kiefer, Falk [VerfasserIn] |
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| | Vollstädt-Klein, Sabine [VerfasserIn] |
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| Titel: | Investigation of brain functional connectivity to assess cognitive control over cue-processing in alcohol use disorder |
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| Verf.angabe: | Alicia Strosche, Xiaochu Zhang, Martina Kirsch, Derik Hermann, Gabriele Ende, Falk Kiefer, Sabine Vollstädt‐Klein |
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| Jahr: | 2021 |
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| Jahr des Originals: | 2020 |
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| Umfang: | 13 S. |
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| Fussnoten: | First published: 06 January 2020 ; Gesehen am 27.04.2021 |
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| Titel Quelle: | Enthalten in: Addiction biology |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1996 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 26(2021), 1 vom: Jan., Artikel-ID e12863, Seite 1-13 |
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| ISSN Quelle: | 1355-6215 |
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| Abstract: | Alcohol Use Disorder has been associated with impairments of functional connectivity between neural networks underlying reward processing and cognitive control. Evidence for aberrant functional connectivity between the striatum, insula, and frontal cortex in alcohol users exists at rest, but not during cue-exposure. In this study, we investigated functional connectivity changes during a cue-reactivity task across different subgroups of alcohol consumers. Ninety-six participants (ranging from light social to heavy social drinkers and nonabstinent dependent to abstinent dependent drinkers) were examined. A functional magnetic resonance imaging cue-reactivity paradigm was administered, during which alcohol-related and neutral stimuli were presented. Applying psychophysiological interaction analyses, we found: (a) Abstinent alcohol-dependent patients compared with non-abstinent dependent drinkers showed a greater increase of functional connectivity of the ventral striatum and anterior insula with the anterior cingulate cortex and dorsolateral prefrontal cortex during the presentation of alcohol cues compared with neutral cues. (b) Subjective craving correlated positively with functional connectivity change between the posterior insula and the medial orbitofrontal cortex and negatively with functional connectivity change between the ventral striatum and the anterior cingulate cortex, dorsolateral prefrontal cortex, and lateral orbitofrontal cortex. (c) Compulsivity of alcohol use correlated positively with functional connectivity change between the dorsolateral prefrontal cortex and the ventral striatum, anterior insula, and posterior insula. Results suggest increased cognitive control over cue-processing in abstinent alcohol-dependent patients, compensating high levels of cue-provoked craving and compulsive use. Clinical trial registration details: ClinicalTrials.gov ID: NCT00926900 |
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| DOI: | doi:10.1111/adb.12863 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/https://doi.org/10.1111/adb.12863 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12863 |
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| | DOI: https://doi.org/10.1111/adb.12863 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | alcohol use disorder |
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| | craving |
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| | cue-reactivity |
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| | fMRI |
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| | functional connectivity |
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| | psychophysiological interaction |
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| K10plus-PPN: | 1755999585 |
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| Verknüpfungen: | → Zeitschrift |
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Investigation of brain functional connectivity to assess cognitive control over cue-processing in alcohol use disorder / Strosche, Alicia [VerfasserIn]; 2021 (Online-Ressource)
