Status: Bibliographieeintrag
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| Verfasst von: | Carmen Aguilar Lemarroy, Adriana del [VerfasserIn]  |
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| | Zur Hausen, Harald [VerfasserIn] |
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| | Krammer, Peter H. [VerfasserIn] |
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| | Rösl, Frank [VerfasserIn] |
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| Titel: | Differential sensitivity of human papillomavirus type 16+ and type 18+ cervical carcinoma cells to CD95-mediated apoptosis |
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| Verf.angabe: | Adriana Aguilar‐Lemarroy, Sabine Kirchhoff, Noel Whitaker, Patricio Gariglio, Harald zur Hausen, Peter H. Krammer and Frank Rösl |
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| E-Jahr: | 2001 |
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| Jahr: | 13 August 2001 |
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| Umfang: | 9 S. |
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| Teil: | volume:93 |
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| | year:2001 |
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| | number:6 |
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| | pages:823-831 |
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| | extent:9 |
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| Fussnoten: | Gesehen am 27.04.2021 ; Im Titel sind die Pluszeichen hochgestellt |
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| Titel Quelle: | Enthalten in: International journal of cancer |
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| Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
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| Jahr Quelle: | 2001 |
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| Band/Heft Quelle: | 93(2001), 6, Seite 823-831 |
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| ISSN Quelle: | 1097-0215 |
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| Abstract: | When cervical carcinoma cells were monitored for apoptotic signals, HPV18+ lines were found to be highly sensitive to agonistic CD95 antibodies or recombinant CD95 ligands after co-exposure with CHX (CD95S). In contrast, HPV16+ cervical carcinoma cells and HPV16-immortalized non-malignant human keratinocytes were CD95-resistant (CD95R) under equivalent conditions. Somatic cell hybridization between CD95S and CD95R cervical carcinoma cell lines revealed that CD95 sensitivity was a dominant trait, which could be correlated with abundant c-Myc and low Bcl-XL expression. Although CD95R cervical carcinoma cells expressed even higher levels of p53 and CD95 receptor at the surface, resistance could be attributed to the inability to form a functional DISC, necessary for successful transmission of the apoptogenic response. These data indicate that resistance to apoptotic stimuli represents an important immunological escape mechanism during virus-induced carcinogenesis. |
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| DOI: | doi:10.1002/ijc.1405 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/https://doi.org/10.1002/ijc.1405 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.1405 |
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| | DOI: https://doi.org/10.1002/ijc.1405 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | apoptosis |
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| | CD95 |
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| | cervical cancer |
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| | human papillomavirus |
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| | immunological surveillance |
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| | somatic cell hybrids |
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| K10plus-PPN: | 1756022488 |
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| Verknüpfungen: | → Zeitschrift |
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Differential sensitivity of human papillomavirus type 16+ and type 18+ cervical carcinoma cells to CD95-mediated apoptosis / Carmen Aguilar Lemarroy, Adriana del [VerfasserIn]; 13 August 2001 (Online-Ressource)
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