| |  Online-Ressource |
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| Verfasst von: | Moreau, Catherine [VerfasserIn]  |
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| | Quadt, Katharina [VerfasserIn] |
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| | Piirainen, Henni [VerfasserIn] |
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| | Kumar, Hirdesh [VerfasserIn] |
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| | Bhargav, Saligram P. [VerfasserIn] |
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| | Strauss, Léanne [VerfasserIn] |
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| | Tolia, Niraj H. [VerfasserIn] |
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| | Wade, Rebecca C. [VerfasserIn] |
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| | Spatz, Joachim P. [VerfasserIn] |
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| | Kursula, Inari [VerfasserIn] |
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| | Frischknecht, Friedrich [VerfasserIn] |
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| Titel: | A function of profilin in force generation during malaria parasite motility that is independent of actin binding |
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| Verf.angabe: | Catherine A. Moreau, Katharina A. Quadt, Henni Piirainen, Hirdesh Kumar, Saligram P. Bhargav, Léanne Strauss, Niraj H. Tolia, Rebecca C. Wade, Joachim P. Spatz, Inari Kursula and Friedrich Frischknecht |
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| Jahr: | 2021 |
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| Umfang: | 12 S. |
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| Teil: | volume:134 |
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| | year:2021 |
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| | number:5 |
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| | elocationid:jcs233775 |
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| | pages:1-12 |
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| | extent:12 |
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| Fussnoten: | [Online veröffentlicht] 25 April 2020 ; Gesehen am 03.08.2021 |
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| Titel Quelle: | Enthalten in: Journal of cell science |
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| Ort Quelle: | Cambridge : Company of Biologists Limited, 1853 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 134(2021), 5, Artikel-ID jcs233775, Seite 1-12 |
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| ISSN Quelle: | 1477-9137 |
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| Abstract: | During transmission of malaria-causing parasites from mosquito to mammal, Plasmodium sporozoites migrate at high speed within the skin to access the bloodstream and infect the liver. This unusual gliding motility is based on retrograde flow of membrane proteins and highly dynamic actin filaments that provide short tracks for a myosin motor. Using laser tweezers and parasite mutants, we previously suggested that actin filaments form macromolecular complexes with plasma membrane-spanning adhesins to generate force during migration. Mutations in the actin-binding region of profilin, a near ubiquitous actin-binding protein, revealed that loss of actin binding also correlates with loss of force production and motility. Here, we show that different mutations in profilin, that do not affect actin binding in vitro, still generate lower force during Plasmodium sporozoite migration. Lower force generation inversely correlates with increased retrograde flow suggesting that, like in mammalian cells, the slow down of flow to generate force is the key underlying principle governing Plasmodium gliding motility. |
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| DOI: | doi:10.1242/jcs.233775 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1242/jcs.233775 |
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| | DOI: https://doi.org/10.1242/jcs.233775 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1756126364 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ function of profilin in force generation during malaria parasite motility that is independent of actin binding / Moreau, Catherine [VerfasserIn]; 2021 (Online-Ressource)
