| |  Online-Ressource |
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| Verfasst von: | Amininasab, Mehriar [VerfasserIn]  |
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| | Elmi, Maryam M. [VerfasserIn] |
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| | Endlich, Nicole [VerfasserIn] |
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| | Endlich, Karlhans [VerfasserIn] |
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| | Parekh, Niranjan [VerfasserIn] |
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| | Naderi-Manesh, Hossein [VerfasserIn] |
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| | Schaller, Johann [VerfasserIn] |
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| | Mostafavi, Hossein [VerfasserIn] |
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| | Sattler, Michael [VerfasserIn] |
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| | Sarbolouki, Mohammad N. [VerfasserIn] |
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| | Muhle-Goll, Claudia [VerfasserIn] |
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| Titel: | Functional and structural characterization of a novel member of the natriuretic family of peptides from the venom of Pseudocerastes persicus |
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| Verf.angabe: | Mehriar Amininasab, Maryam M. Elmi, Nicole Endlich, Karlhans Endlich, Niranjah Parekh, Hossein Naderi-Manesh, Johann Schaller, Hossein Mostafavi, Michael Sattler, Mohammad N. Sarbolouki, Claudia Muhle-Goll |
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| Jahr: | 2004 |
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| Umfang: | 5 S. |
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| Fussnoten: | Published: 19 December 2003 ; Gesehen am 28.04.2021 |
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| Titel Quelle: | Enthalten in: Vereinigung der Europäischen Biochemischen GesellschaftenFEBS letters |
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| Ort Quelle: | Chichester : Wiley, 1968 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 557(2004), 1/3, Seite 104-108 |
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| ISSN Quelle: | 1873-3468 |
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| Abstract: | A novel peptide, PNP ( seudocerastes persicus atriuretic eptide), was isolated from the venom of the Iranian viper P. persicus. Amino acid sequencing revealed that the 37-residue peptide belongs to the family of natriuretic peptides. The physiological effects of intra-venously PNP infused into anesthetized rats on urine flow, sodium excretion and blood pressure were comparable to those of atrial natriuretic peptide (ANP). In PC12 cells that were treated with either PNP, ANP, or C-type natriuretic peptide, PNP induced a similar cGMP response as ANP. Since PC12 cells only express the natriuretic peptide receptor (NPR)-A receptor we conclude that PNP binds to the NPR-A receptor. The solution conformation of PNP was characterized using 1H nuclear magnetic resonance spectroscopy and indicates a high degree of conformational flexibility. |
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| DOI: | doi:10.1016/S0014-5793(03)01455-8 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/https://doi.org/10.1016/S0014-5793(03)01455-8 |
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| | Volltext: https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/S0014-5793%2803%2901455-8 |
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| | DOI: https://doi.org/10.1016/S0014-5793(03)01455-8 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ANP |
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| | atrial natriuretic peptide |
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| | BNP |
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| | brain natriuretic peptide |
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| | C-type natriuretic peptide |
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| | CNP |
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| | Natriuretic peptide |
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| | natriuretic peptide receptor A |
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| | natriuretic peptide receptor B |
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| | natriuretic peptide receptor C |
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| | NMR |
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| | NOE |
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| | NOESY |
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| | NPR-A |
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| | NPR-B |
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| | NPR-C |
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| | nuclear magnetic resonance |
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| | Nuclear magnetic resonance characterization |
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| | nuclear Overhauser effect |
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| | PNP |
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| | Pseudocerastes persicus natriuretic peptide |
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| | Snake venom |
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| | TOCSY |
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| | total correlation spectroscopy |
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| | two-dimensional NOE correlation spectroscopy |
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| K10plus-PPN: | 1756150885 |
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| Verknüpfungen: | → Zeitschrift |
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Functional and structural characterization of a novel member of the natriuretic family of peptides from the venom of Pseudocerastes persicus / Amininasab, Mehriar [VerfasserIn]; 2004 (Online-Ressource)
