| |  Online-Ressource |
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| Verfasst von: | Zowada, Martina [VerfasserIn]  |
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| | Tirier, Stephan Marius [VerfasserIn] |
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| | Dieter, Sebastian M. [VerfasserIn] |
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| | Krieger, Teresa G. [VerfasserIn] |
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| | Oberlack, Ava [VerfasserIn] |
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| | Chua, Robert Lorenz [VerfasserIn] |
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| | Huerta, Mario [VerfasserIn] |
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| | Ten, Foo Wei [VerfasserIn] |
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| | Laaber, Karin [VerfasserIn] |
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| | Park, Jeongbin [VerfasserIn] |
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| | Jechow, Katharina [VerfasserIn] |
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| | Müller, Torsten [VerfasserIn] |
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| | Kalxdorf, Mathias [VerfasserIn] |
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| | Kriegsmann, Mark [VerfasserIn] |
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| | Kriegsmann, Katharina [VerfasserIn] |
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| | Herbst, Friederike [VerfasserIn] |
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| | Krijgsveld, Jeroen [VerfasserIn] |
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| | Schneider, Martin [VerfasserIn] |
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| | Eils, Roland [VerfasserIn] |
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| | Glimm, Hanno [VerfasserIn] |
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| | Conrad, Christian [VerfasserIn] |
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| | Ball, Claudia R. [VerfasserIn] |
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| Titel: | Functional states in tumor-initiating cell differentiation in human colorectal cancer |
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| Verf.angabe: | Martina K. Zowada, Stephan M. Tirier, Sebastian M. Dieter, Teresa G. Krieger, Ava Oberlack, Robert Lorenz Chua, Mario Huerta, Foo Wei Ten, Karin Laaber, Jeongbin Park, Katharina Jechow, Torsten Müller, Mathias Kalxdorf, Mark Kriegsmann, Katharina Kriegsmann, Friederike Herbst, Jeroen Krijgsveld, Martin Schneider, Roland Eils, Hanno Glimm, Christian Conrad and Claudia R. Ball |
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| E-Jahr: | 2021 |
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| Jahr: | 4 March 2021 |
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| Umfang: | 32 S. |
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| Fussnoten: | Gesehen am 30.07.2021 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 5, Artikel-ID 1097, Seite 1-32 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Intra-tumor heterogeneity of tumor-initiating cell (TIC) activity drives colorectal cancer (CRC) progression and therapy resistance. Here, we used single-cell RNA-sequencing of patient-derived CRC models to decipher distinct cell subpopulations based on their transcriptional profiles. Cell type-specific expression modules of stem-like, transit amplifying-like, and differentiated CRC cells resemble differentiation states of normal intestinal epithelial cells. Strikingly, identified subpopulations differ in proliferative activity and metabolic state. In summary, we here show at single-cell resolution that transcriptional heterogeneity identifies functional states during TIC differentiation. Furthermore, identified expression signatures are linked to patient prognosis. Targeting transcriptional states associated to cancer cell differentiation might unravel novel vulnerabilities in human CRC. |
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| DOI: | doi:10.3390/cancers13051097 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/cancers13051097 |
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| | Volltext: https://www.mdpi.com/2072-6694/13/5/1097 |
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| | DOI: https://doi.org/10.3390/cancers13051097 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | colorectal cancer |
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| | patient-derived cancer models |
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| | single-cell RNA-sequencing |
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| | transcriptional programs |
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| | tumor cell differentiation |
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| | tumor heterogeneity |
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| | tumor metabolism |
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| | tumor-initiating cells |
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| K10plus-PPN: | 1756555265 |
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| Verknüpfungen: | → Zeitschrift |
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Functional states in tumor-initiating cell differentiation in human colorectal cancer / Zowada, Martina [VerfasserIn]; 4 March 2021 (Online-Ressource)
