Growth differentiation factor-15 as a potent predictor of long-term mortality among subjects with osteoarthritis

• Verfasst von: Arnold, Natalie [VerfasserIn]
• Verfasst von: Rehm, Martin [VerfasserIn]
• Verfasst von: Büchele, Gisela [VerfasserIn]
• Verfasst von: Peter, Raphael Simon [VerfasserIn]
• Verfasst von: Brenner, Rolf Erwin [VerfasserIn]
• Verfasst von: Günther, Klaus-Peter [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Koenig, Wolfgang [VerfasserIn]
• Verfasst von: Rothenbacher, Dietrich [VerfasserIn]
• Titel: Growth differentiation factor-15 as a potent predictor of long-term mortality among subjects with osteoarthritis
• Verf.angabe: Natalie Arnold, Martin Rehm, Gisela Büchele, Raphael Simon Peter, Rolf Erwin Brenner, Klaus-Peter Günther, Hermann Brenner, Wolfgang Koenig, and Dietrich Rothenbacher
• E-Jahr: 2020
• Jahr: 26 September 2020
• Umfang: 14 S.
• Teil: volume:9
• Teil: year:2020
• Teil: number:10
• Teil: elocationid:3107
• Teil: pages:1-14
• Teil: extent:14
• Fussnoten: Gesehen am 29.04.2021
• Titel Quelle: Enthalten in: Journal of Clinical Medicine
• Ort Quelle: Basel : MDPI, 2012
• Jahr Quelle: 2020
• Band/Heft Quelle: 9(2020), 10, Artikel-ID 3107, Seite 1-14
• ISSN Quelle: 2077-0383
• DOI: doi:10.3390/jcm9103107
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: growth differentiation factor-15
• Sach-SW: osteoarthritis
• Sach-SW: prognosis
• Sach-SW: total mortality
• K10plus-PPN: 175656440X

Abstract

Background: Subjects with osteoarthritis (OA) are at increased risk for cardiovascular (CV) and all-cause mortality. Whether biomarkers improve outcome prediction in these patients remains to be elucidated. We investigated the association between growth differentiation factor 15 (GDF-15), a novel stress-responsive cytokine, and long-term all-cause mortality among OA patients. Methods: Within the Ulm Osteoarthritis Study, GDF-15 has been measured in the serum of 636 subjects, who underwent hip or knee arthroplasty between 1995 and 1996 (median age 65 years). Results: During a median follow-up of 19.7 years, a total of 402 deaths occurred. GDF-15 was inversely associated with walking distance. Compared to the bottom quartile (Q), subjects within the top quartile of GDF-15 demonstrated a 2.69-fold increased risk of dying (hazard ratio (HR) (95% confidence interval (CI)) 2.69 (1.82&ndash;3.96) adjusted for age, sex, BMI, smoking status, localization of OA, diabetes, maximum walking distance, total cholesterol, and cystatin C. Further adjustment for NT-proBNP, troponin I, and hs-C-reactive protein did not change the results appreciably (HR (95%CI) 1.56 (1.07&ndash;2.28); 1.75 (1.21&ndash;2.55); 2.32 (1.55&ndash;3.47) for Q2, Q3, and Q4 respectively, p for trend < 0.001). Conclusions: In subjects with OA, GDF-15 represents a potent predictor of decreased survival over >20 years, independently of conventional CV risk factors, renal, cardiac, and inflammatory biomarkers as well as walking disability, previously associated with increased mortality and lower extremity OA.