Plasmodium reproduction, cell size, and transcription

• Verfasst von: Machado, Marta [VerfasserIn]
• Verfasst von: Steinke, Salome [VerfasserIn]
• Verfasst von: Ganter, Markus [VerfasserIn]
• Titel: Plasmodium reproduction, cell size, and transcription
• Titelzusatz: How to Cope With Increasing DNA Content?
• Verf.angabe: Marta Machado, Salome Steinke and Markus Ganter
• E-Jahr: 2021
• Jahr: 09 April 2021
• Umfang: 8 S.
• Teil: volume:11
• Teil: year:2021
• Teil: month:04
• Teil: elocationid:660679
• Teil: extent:8
• Fussnoten: Gesehen am 29.04.2021
• Titel Quelle: Enthalten in: Frontiers in Cellular and Infection Microbiology
• Ort Quelle: Lausanne : Frontiers Media, 2010
• Jahr Quelle: 2021
• Band/Heft Quelle: 11(2021) vom: Apr., Artikel-ID 660679
• ISSN Quelle: 2235-2988
• DOI: doi:10.3389/fcimb.2021.660679
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: DNA content
• Sach-SW: Gene Dosage
• Sach-SW: Gene experession
• Sach-SW: Malaria
• Sach-SW: Plasmodium
• Sach-SW: Polyploidy
• Sach-SW: Transcription Regulation
• K10plus-PPN: 1756573298
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Plasmodium, the unicellular parasite that causes malaria, evolved a highly unusual mode of re-production. During its complex life cycle, invasive or transmissive stages alternate with proliferating stages, where a single parasite can produce tens of thousands of progeny. In the clinically rele-vant blood stage of infection, the parasite replicates its genome up to thirty times and forms a multinucleated cell before daughter cells are assembled. Thus, within a single cell cycle, Plasmo-dium develops from a haploid to a polypoid cell, harboring multiple copies of its genome. Poly-ploidy creates several biological challenges, such as imbalances in genome output, and cells can respond to this by changing their size and/or alter the production of RNA species and protein to achieve expression homeostasis. However, the effects and possible adaptations of Plasmodium to the massively increasing DNA content are unknown. Here, we revisit and embed current Plas-modium literature in the context of polyploidy and propose potential mechanisms of the parasite to cope with the increasing gene dosage.