Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Colasante, Claudia [VerfasserIn]   i
 Voncken, Frank [VerfasserIn]   i
 Manful, Theresa [VerfasserIn]   i
 Ruppert, Thomas [VerfasserIn]   i
 Tielens, Aloysius G M [VerfasserIn]   i
 van Hellemond, Jaap J [VerfasserIn]   i
 Clayton, Christine [VerfasserIn]   i
Titel:Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei
Verf.angabe:Claudia Colasante, Frank Voncken, Theresa Manful, Thomas Ruppert, Aloysius G.M. Tielens, Jaap J. van Hellemond, Christine Clayton
E-Jahr:2013
Jahr:29 Jan 2013
Umfang:16 S.
Teil:volume:2
 year:2013
 elocationid:27
 pages:1-16
 extent:16
Fussnoten:Gesehen am 30.04.2021
Titel Quelle:Enthalten in: F1000Research
Ort Quelle:London : F1000 Research Ltd, 2012
Jahr Quelle:2013
Band/Heft Quelle:2(2013), Artikel-ID 27, Seite 1-16
ISSN Quelle:2046-1402
Abstract:In kinetoplastid protists, several metabolic pathways, including glycolysis and purine salvage, are located in glycosomes, which are microbodies that are evolutionarily related to peroxisomes. With the exception of some potential transporters for fatty acids, and one member of the mitochondrial carrier protein family, proteins that transport metabolites across the glycosomal membrane have yet to be identified. We show here that the phosphatidylcholine species composition of - Trypanosoma brucei glycosomal membranes resembles that of other cellular membranes, which means that glycosomal membranes are expected to be impermeable to small hydrophilic molecules unless transport is facilitated by specialized membrane proteins. Further, we identified 464 proteins in a glycosomal membrane preparation from - Leishmania tarentolae. The proteins included approximately 40 glycosomal matrix proteins, and homologues of peroxisomal membrane proteins - PEX11, GIM5A and GIM5B; PXMP4, PEX2 and PEX16 - as well as the transporters GAT1 and GAT3. There were 27 other proteins that could not be unambiguously assigned to other compartments, and that had predicted trans-membrane domains. However, no clear candidates for transport of the major substrates and intermediates of energy metabolism were found. We suggest that, instead, these metabolites are transported via pores formed by the known glycosomal membrane proteins.
DOI:doi:10.12688/f1000research.2-27.v1
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.12688/f1000research.2-27.v1
 Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814921/
 DOI: https://doi.org/10.12688/f1000research.2-27.v1
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1756643989
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68731006   QR-Code
zum Seitenanfang