| |
 Online-Ressource | |
| Verfasst von: | Bernal, Laura [VerfasserIn]  |
| Sotelo-Hitschfeld, Pamela [VerfasserIn] | |
| König, Christine [VerfasserIn] | |
| Sinica, Viktor [VerfasserIn] | |
| Wyatt, Amanda [VerfasserIn] | |
| Winter, Zoltan [VerfasserIn] | |
| Hein, Alexander [VerfasserIn] | |
| Touska, Filip [VerfasserIn] | |
| Reinhardt, Susanne [VerfasserIn] | |
| Tragl, Aaron [VerfasserIn] | |
| Kusuda, Ricardo [VerfasserIn] | |
| Wartenberg, Philipp [VerfasserIn] | |
| Sclaroff, Allen [VerfasserIn] | |
| Pfeifer, John D. [VerfasserIn] | |
| Ectors, Fabien [VerfasserIn] | |
| Dahl, Andreas [VerfasserIn] | |
| Freichel, Marc [VerfasserIn] | |
| Vlachova, Viktorie [VerfasserIn] | |
| Brauchi, Sebastian [VerfasserIn] | |
| Roza, Carolina [VerfasserIn] | |
| Boehm, Ulrich [VerfasserIn] | |
| Clapham, David E. [VerfasserIn] | |
| Lennerz, Jochen K. [VerfasserIn] | |
| Zimmermann, Katharina [VerfasserIn] | |
| Titel: | Odontoblast TRPC5 channels signal cold pain in teeth |
| Verf.angabe: | Laura Bernal, Pamela Sotelo-Hitschfeld, Christine König, Viktor Sinica, Amanda Wyatt, Zoltan Winter, Alexander Hein, Filip Touska, Susanne Reinhardt, Aaron Tragl, Ricardo Kusuda, Philipp Wartenberg, Allen Sclaroff, John D. Pfeifer, Fabien Ectors, Andreas Dahl, Marc Freichel, Viktorie Vlachova, Sebastian Brauchi, Carolina Roza, Ulrich Boehm, David E. Clapham, Jochen K. Lennerz, Katharina Zimmermann |
| E-Jahr: | 2021 |
| Jahr: | 26 March 2021 |
| Umfang: | 1-13$p13 S. |
| Teil: | volume:7 |
| year:2021 | |
| number:13 | |
| elocationid:eabf5567 | |
| extent:1-13$p13 | |
| Fussnoten: | Gesehen am 28.07.2021 |
| Titel Quelle: | Enthalten in: Science advances |
| Ort Quelle: | Washington, DC [u.a.] : Assoc., 2015 |
| Jahr Quelle: | 2021 |
| Band/Heft Quelle: | 7(2021), 13, Artikel-ID eabf5567 |
| ISSN Quelle: | 2375-2548 |
| Abstract: | Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms of this cold sensation are not understood. Here, we clarify the molecular and cellular components of the dental cold sensing system and show that sensory transduction of cold stimuli in teeth requires odontoblasts. TRPC5 is a cold sensor in healthy teeth and, with TRPA1, is sufficient for cold sensing. The odontoblast appears as the direct site of TRPC5 cold transduction and provides a mechanism for prolonged cold sensing via TRPC5’s relative sensitivity to intracellular calcium and lack of desensitization. Our data provide concrete functional evidence that equipping odontoblasts with the cold-sensor TRPC5 expands traditional odontoblast functions and renders it a previously unknown integral cellular component of the dental cold sensing system. - The odontoblast, with processes beyond the dentin-enamel boundary, is the initial site of TRPC5 cold transduction in teeth. - The odontoblast, with processes beyond the dentin-enamel boundary, is the initial site of TRPC5 cold transduction in teeth. |
| DOI: | doi:10.1126/sciadv.abf5567 |
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext ; Verlag: https://doi.org/10.1126/sciadv.abf5567 |
| Volltext: https://advances.sciencemag.org/content/7/13/eabf5567 | |
| DOI: https://doi.org/10.1126/sciadv.abf5567 | |
| Datenträger: | Online-Ressource |
| Sprache: | eng |
| K10plus-PPN: | 1756663750 |
| Verknüpfungen: | → Zeitschrift |
