Differential actions of spinal analgesics on mono-versus polysynaptic Aδ-fibre-evoked field potentials in superficial spinal dorsal horn in vitro

• Verfasst von: Ruscheweyh, Ruth [VerfasserIn]
• Verfasst von: Sandkühler, Jürgen [VerfasserIn]
• Titel: Differential actions of spinal analgesics on mono-versus polysynaptic Aδ-fibre-evoked field potentials in superficial spinal dorsal horn in vitro
• Verf.angabe: Ruth Ruscheweyh, Jürgen Sandkühler
• E-Jahr: 2000
• Jahr: October 2000
• Umfang: 12 S.
• Teil: volume:88
• Teil: year:2000
• Teil: number:1
• Teil: pages:97-108
• Teil: extent:12
• Fussnoten: Gesehen am 04.05.2021
• Titel Quelle: Enthalten in: Pain
• Ort Quelle: New York, NY [u.a.] : Lippincott Williams and Wilkins, 1975
• Jahr Quelle: 2000
• Band/Heft Quelle: 88(2000), 1, Seite 97-108
• ISSN Quelle: 1872-6623
• DOI: doi:10.1016/S0304-3959(00)00325-0
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1757029516

Abstract

Processing of nociceptive information can be modulated at various levels in spinal cord that may range from changes of neurotransmitter release from primary afferent Aδ- or C-fibres to excitability changes of spinal interneurones or motoneurones. The site and mechanism of action of spinal analgesics has been assessed with a number of in vivo and in vitro methods with sometimes conflicting results. Here, we have used transverse spinal cord slices with attached dorsal roots to simultaneously record mono- and polysynaptic Aδ-fibre-evoked field potentials in superficial spinal dorsal horn. Two classical spinal analgesics, morphine and clonidine, and the metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) differentially affected mono- and polysynaptic Aδ-fibre-evoked transmission in spinal dorsal horn. Polysynaptic responses were dose-dependently inhibited while the monosynaptic response remained unaffected. These results suggest that spinal analgesics may preferentially affect polysynaptic but not monosynaptic Aδ-fibre-evoked responses in superficial spinal dorsal horn.