Effects of chronic isovolaemic haemodilution on regional cerebral blood flow in conscious rats

• Verfasst von: Frietsch, Thomas [VerfasserIn]
• Verfasst von: Lenz, Christian [VerfasserIn]
• Verfasst von: Kuschinsky, Wolfgang [VerfasserIn]
• Verfasst von: Waschke, Klaus F. [VerfasserIn]
• Titel: Effects of chronic isovolaemic haemodilution on regional cerebral blood flow in conscious rats
• Verf.angabe: T. Frietsch, C. Lenz, W. Kuschinsky, K.F. Waschke
• E-Jahr: 2004
• Jahr: [2004]
• Umfang: 7 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 05.05.2021
• Titel Quelle: Enthalten in: European journal of anaesthesiology
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1996
• Jahr Quelle: 2004
• Band/Heft Quelle: 21(2004), 1 vom: Jan., Seite 53-59
• ISSN Quelle: 1365-2346
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1757111921

Abstract

Background and objective: - Acute isovolaemic haemodilution increases local and mean cerebral blood flow. It is not known whether a single haemodilution has a short-term effect only or whether it affects cerebral perfusion over a longer time period. In the present study, local and mean cerebral blood flow were determined in conscious rats after a 4, 24 and 48 h period following one-time haemodilution. - Methods: - Thirty-six rats were randomized to three untreated sham groups and three groups of haemodilution (4, 24 or 48 h, n = 6 for each group). Isovolaemic haemodilution with albumin 5% aimed to a target haematocrit of 0.2. Local cerebral blood flow was measured in 38 brain regions by the iodo-[14C]antipyrine method in conscious normothermic rats. - Results: - Isovolaemic haemodilution reduced haematocrit from 0.44 to 0.20. During the following 24 and 48 h periods, haematocrit remained low (0.22 and 0.21). Mean cerebral blood flow was similar in untreated sham groups (88 ± 12 after 4 h, 92 ± 11 after 24 h, 96 ± 10 mL 100 g−1 min−1 after 48 h). Haemodilution increased mean cerebral blood flow after 4 h (184 ± 11 mL 100 g−1 min−1), after 24 h (153 ± 13 mL 100 g−1 min−1) and 48 h (149 ± 15 mL 100 g−1 min−1) (P ≤ 0.05). Local cerebral blood flow increased in all 38 structures after 4 h haemodilution but decreased with time in six of 38 brain structures after 24 h and in 15 regions after 48 h (P ≤ 0.05). - Conclusions: - A single one-time haemodilution increased mean cerebral blood flow for 2 days. However, local adaptation of cerebral blood flow to a chronic low haematocrit occurred but was heterogeneous within the brain.