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Verfasst von:Fütterer, Carsten Dietmar [VerfasserIn]   i
 Maurer, Martin H. [VerfasserIn]   i
 Schmitt, Anne [VerfasserIn]   i
 Feldmann, Robert Enrico [VerfasserIn]   i
 Kuschinsky, Wolfgang [VerfasserIn]   i
 Waschke, Klaus F. [VerfasserIn]   i
Titel:Alterations in rat brain proteins after desflurane anesthesia
Verf.angabe:Carsten D. Fütterer, Martin H. Maurer, Anne Schmitt, Robert E. Feldmann, Wolfgang Kuschinsky, Klaus F. Waschke
E-Jahr:2004
Jahr:[Feb 2004]
Umfang:7 S.
Fussnoten:Gesehen am 05.05.2021
Titel Quelle:Enthalten in: Anesthesiology
Ort Quelle:Hagerstown, Md. : Lippincott Williams & Wilkins, 1940
Jahr Quelle:2004
Band/Heft Quelle:100(2004), 2 vom: Feb., Seite 302-308
ISSN Quelle:1528-1175
Abstract:Volatile anesthetics disappear from an organism after the end of anesthesia. Whether changes of protein expression persist in the brain for a longer period is not known. This study investigates the question of whether the expression of proteins is altered in the rat brain after the end of desflurane anesthesia.Three groups (n = 12 each) of rats were anesthetized with 5.7% desflurane in air for 3 h. Brains were removed directly after anesthesia, 24 h after anesthesia, or 72 h after anesthesia. Two additional groups (n = 12 each) served as naive conscious controls, in which the brains were removed without previous anesthesia 3 or 72 h after the start of the experiment. Cytosolic proteins were isolated. A proteome-wide study was performed, based on two-dimensional gel electrophoresis and mass spectrometry.Compared with conscious controls, significant (P < 0.05) increase/decrease was found: 3 h of anesthesia, 5/2 proteins; 24 h after anesthesia, 13/1 proteins; 72 h after anesthesia, 6/4 proteins. The overall changes in protein expression as quantified by the induction factor ranged from -1.67 (decrease to 60%) to 1.79 (increase by 79%) compared with the controls (100%). Some of these regulated proteins play a role in vesicle transport and metabolism.Desflurane anesthesia produces changes in cytosolic protein expression up to 72 h after anesthesia in the rat brain, indicating yet unknown persisting effects.
DOI:doi:10.1097/00000542-200402000-00019
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/00000542-200402000-00019
 DOI: https://doi.org/10.1097/00000542-200402000-00019
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:175712621X
Verknüpfungen:→ Zeitschrift

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