| Online-Ressource |
Verfasst von: | Fütterer, Carsten Dietmar [VerfasserIn]  |
| Maurer, Martin H. [VerfasserIn]  |
| Schmitt, Anne [VerfasserIn]  |
| Feldmann, Robert Enrico [VerfasserIn]  |
| Kuschinsky, Wolfgang [VerfasserIn]  |
| Waschke, Klaus F. [VerfasserIn]  |
Titel: | Alterations in rat brain proteins after desflurane anesthesia |
Verf.angabe: | Carsten D. Fütterer, Martin H. Maurer, Anne Schmitt, Robert E. Feldmann, Wolfgang Kuschinsky, Klaus F. Waschke |
E-Jahr: | 2004 |
Jahr: | [Feb 2004] |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 05.05.2021 |
Titel Quelle: | Enthalten in: Anesthesiology |
Ort Quelle: | Hagerstown, Md. : Lippincott Williams & Wilkins, 1940 |
Jahr Quelle: | 2004 |
Band/Heft Quelle: | 100(2004), 2 vom: Feb., Seite 302-308 |
ISSN Quelle: | 1528-1175 |
Abstract: | Volatile anesthetics disappear from an organism after the end of anesthesia. Whether changes of protein expression persist in the brain for a longer period is not known. This study investigates the question of whether the expression of proteins is altered in the rat brain after the end of desflurane anesthesia.Three groups (n = 12 each) of rats were anesthetized with 5.7% desflurane in air for 3 h. Brains were removed directly after anesthesia, 24 h after anesthesia, or 72 h after anesthesia. Two additional groups (n = 12 each) served as naive conscious controls, in which the brains were removed without previous anesthesia 3 or 72 h after the start of the experiment. Cytosolic proteins were isolated. A proteome-wide study was performed, based on two-dimensional gel electrophoresis and mass spectrometry.Compared with conscious controls, significant (P < 0.05) increase/decrease was found: 3 h of anesthesia, 5/2 proteins; 24 h after anesthesia, 13/1 proteins; 72 h after anesthesia, 6/4 proteins. The overall changes in protein expression as quantified by the induction factor ranged from -1.67 (decrease to 60%) to 1.79 (increase by 79%) compared with the controls (100%). Some of these regulated proteins play a role in vesicle transport and metabolism.Desflurane anesthesia produces changes in cytosolic protein expression up to 72 h after anesthesia in the rat brain, indicating yet unknown persisting effects. |
DOI: | doi:10.1097/00000542-200402000-00019 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1097/00000542-200402000-00019 |
| DOI: https://doi.org/10.1097/00000542-200402000-00019 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 175712621X |
Verknüpfungen: | → Zeitschrift |
Alterations in rat brain proteins after desflurane anesthesia / Fütterer, Carsten Dietmar [VerfasserIn]; [Feb 2004] (Online-Ressource)