| |  Online-Ressource |
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| Verfasst von: | Maschke, Janina [VerfasserIn]  |
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| | Roetner, Jakob [VerfasserIn] |
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| | Goecke, Tamme W. [VerfasserIn] |
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| | Fasching, Peter A. [VerfasserIn] |
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| | Beckmann, Matthias W. [VerfasserIn] |
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| | Kratz, Oliver Rudolf [VerfasserIn] |
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| | Moll, Gunther H. [VerfasserIn] |
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| | Lenz, Bernd [VerfasserIn] |
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| | Kornhuber, Johannes [VerfasserIn] |
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| | Eichler, Anna [VerfasserIn] |
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| Titel: | Prenatal alcohol exposure and the facial phenotype in adolescents |
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| Titelzusatz: | a study based on meconium ethyl glucuronide |
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| Verf.angabe: | Janina Maschke, Jakob Roetner, Tamme W. Goecke, Peter A. Fasching, Matthias W. Beckmann, Oliver Kratz, Gunther H. Moll, Bernd Lenz, Johannes Kornhuber, Anna Eichler and IMAC-Mind-Consortium |
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| E-Jahr: | 2021 |
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| Jahr: | 25 January 2021 |
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| Umfang: | 20 S. |
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| Fussnoten: | Gesehen am 05.05.2021 |
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| Titel Quelle: | Enthalten in: Brain Sciences |
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| Ort Quelle: | Basel : MDPI AG, 2011 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 11(2021), 2, Artikel-ID 154, Seite 1-20 |
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| ISSN Quelle: | 2076-3425 |
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| Abstract: | Here, we explore the effects of prenatal alcohol exposure (PAE) in adolescence. We investigated associations between meconium ethyl glucoronide (EtG) and facial malformation. For 129 children (66/63 male/female; M = 13.3, SD = 0.32, 12-14 years), PAE was implemented by newborn meconium EtG and maternal self-reports during the third trimester. Cognitive development was operationalized by standardized scores (WISC V). The EtG cut-off values were set at ≥10 ng/g (n = 32, 24.8% EtG10+) and ≥112 ng/g (n = 20, 15.5% EtG112+). The craniofacial shape was measured using FAS Facial Photographic Analysis Software. EtG10+− and EtG112+-affected children exhibited a shorter palpebral fissure length (p = 0.031/p = 0.055). Lip circularity was smaller in EtG112+-affected children (p = 0.026). Maternal self-reports were not associated (p > 0.164). Lip circularity correlated with fluid reasoning (EtG10+ p = 0.031; EtG112+ p = 0.298) and working memory (EtG10+ p = 0.084; EtG112+ p = 0.144). The present study demonstrates visible effects of the facial phenotype in exposed adolescents. Facial malformation was associated with a child’s cognitive performance in the alcohol-exposed group. The EtG biomarker was a better predictor than maternal self-reports. |
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| DOI: | doi:10.3390/brainsci11020154 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/brainsci11020154 |
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| | Volltext: https://www.mdpi.com/2076-3425/11/2/154 |
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| | DOI: https://doi.org/10.3390/brainsci11020154 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | alcohol |
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| | biomarker |
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| | craniofacial shape |
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| | ethyl glucuronide (EtG) |
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| | facial malformations |
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| | inner canthal distance |
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| | intrauterine alcohol exposure |
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| | lip circularity |
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| | meconium |
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| | palpebral fissure length |
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| K10plus-PPN: | 1757138668 |
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| Verknüpfungen: | → Zeitschrift |
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Prenatal alcohol exposure and the facial phenotype in adolescents / Maschke, Janina [VerfasserIn]; 25 January 2021 (Online-Ressource)
