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Verfasst von:Masood, Muhammad Irfan [VerfasserIn]   i
 Naseem, Mahrukh [VerfasserIn]   i
 Warda, Salam A. [VerfasserIn]   i
 Tapia-Laliena, María Angeles [VerfasserIn]   i
 Rehman, Habib ur [VerfasserIn]   i
 Nasim, Muhammad Jawad [VerfasserIn]   i
 Schäfer, Karl Herbert [VerfasserIn]   i
Titel:Environment permissible concentrations of glyphosate in drinking water can influence the fate of neural stem cells from the subventricular zone of the postnatal mouse
Verf.angabe:Muhammad Irfan Masood, Mahrukh Naseem, Salam A. Warda, María Ángeles Tapia-Laliena, Habib ur Rehman, Muhammad Jawad Nasim, Karl Herbert Schäfer
E-Jahr:2021
Jahr:February 2021
Umfang:14 S.
Fussnoten:Gesehen am 05.05.2021
Titel Quelle:Enthalten in: Environmental pollution
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1987
Jahr Quelle:2021
Band/Heft Quelle:270(2021), Artikel-ID 116179, Seite 1-14
ISSN Quelle:1873-6424
Abstract:The developing nervous system is highly vulnerable to environmental toxicants especially pesticides. Glyphosate pesticide induces neurotoxicity both in humans and rodents, but so far only when exposed to higher concentrations. A few studies, however, have also reported the risk of general toxicity of glyphosate at concentrations comparable to allowable limits set up by environmental protection authorities. In vitro data regarding glyphosate neurotoxicity at concentrations comparable to maximum permissible concentrations in drinking water is lacking. In the present study, we established an in vitro assay based upon neural stem cells (NSCs) from the subventricular zone of the postnatal mouse to decipher the effects of two maximum permissible concentrations of glyphosate in drinking water on the basic neurogenesis processes. Our results demonstrated that maximum permissible concentrations of glyphosate recognized by environmental protection authorities significantly reduced the cell migration and differentiation of NSCs as demonstrated by the downregulation of the expression levels of the neuronal ß-tubulin III and the astrocytic S100B genes. The expression of the cytoprotective gene CYP1A1 was downregulated whilst the expression of oxidative stresses indicator gene SOD1 was upregulated. The concentration comparable to non-toxic human plasma concentration significantly induced cytotoxicity and activated Ca2+ signalling in the differentiated culture. Our findings demonstrated that the permissible concentrations of glyphosate in drinking water recognized by environmental protection authorities are capable of inducing neurotoxicity in the developing nervous system.
DOI:doi:10.1016/j.envpol.2020.116179
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.envpol.2020.116179
 Volltext: https://www.sciencedirect.com/science/article/pii/S0269749120368688
 DOI: https://doi.org/10.1016/j.envpol.2020.116179
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cytoprotective
 Environment
 Glyphosate
 Neural stem cells
 Neurotoxicity
K10plus-PPN:1757142258
Verknüpfungen:→ Zeitschrift

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