Status: Bibliographieeintrag
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| Verfasst von: | Adamek, Martina Maria [VerfasserIn]  |
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| | Heyder, J. [VerfasserIn] |
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| | Heinold, Andreas [VerfasserIn] |
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| | Fiedler, Gerd [VerfasserIn] |
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| | Opelz, Gerhard [VerfasserIn] |
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| | Tran, Thuong Hien [VerfasserIn] |
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| Titel: | Characterization of mannose-binding lectin (MBL) variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels |
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| Verf.angabe: | M. Adamek, J. Heyder, A. Heinold, G. Fiedler, G. Opelz & T.H. Tran |
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| E-Jahr: | 2013 |
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| Jahr: | 17 October 2013 |
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| Umfang: | 6 S. |
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| Teil: | volume:82 |
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| | year:2013 |
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| | number:6 |
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| | month:12 |
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| | pages:410-415 |
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| | extent:6 |
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| Fussnoten: | Gesehen am 05.05.2021 |
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| Titel Quelle: | Enthalten in: Tissue antigens |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1971 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 82(2013), 6 vom: Dez., Seite 410-415 |
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| ISSN Quelle: | 1399-0039 |
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| Abstract: | Mannose-binding lectin (MBL) is a major component of the lectin pathway of complement activation. High and low MBL levels have been associated with susceptibility and severity of a variety of infectious and autoimmune diseases. Several single-nucleotide polymorphisms (SNPs) in the promoter region and exon 1 of the MBL2 gene are responsible for variations in serum MBL levels. We developed a sequence-based typing method for allele-specific MBL2 genotyping and measured serum MBL protein levels in 24 German blood donors. We identified the common MBL2 haplotypes including five promoter polymorphisms in linkage with the Q allele and correlated serum MBL levels with the respective genotypes. The genotyping method presented here could provide a basis for confirmatory studies in larger cohorts. |
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| DOI: | doi:10.1111/tan.12232 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/https://doi.org/10.1111/tan.12232 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.12232 |
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| | DOI: https://doi.org/10.1111/tan.12232 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | haplotypes |
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| | mannose-binding lectin |
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| | MBL2 |
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| | sequencing |
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| K10plus-PPN: | 1757185437 |
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| Verknüpfungen: | → Zeitschrift |
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Characterization of mannose-binding lectin (MBL) variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels / Adamek, Martina Maria [VerfasserIn]; 17 October 2013 (Online-Ressource)
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