| |  Online-Ressource |
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| Verfasst von: | Marti, Andreas [VerfasserIn]  |
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| | Ritter, Philipp M. [VerfasserIn] |
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| | Jäger, Richard [VerfasserIn] |
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| | Lazar, Hedvika [VerfasserIn] |
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| | Baltzer, Anna [VerfasserIn] |
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| | Schenkel, Johannes [VerfasserIn] |
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| | Declercq, Wim [VerfasserIn] |
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| | Vandenabeele, Peter [VerfasserIn] |
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| | Jaggi, Rolf [VerfasserIn] |
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| Titel: | Mouse mammary gland involution is associated with cytochrome c release and caspase activation |
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| Verf.angabe: | Andreas Marti, Philipp M. Ritter, Richard Jäger, Hedvika Lazar, Anna Baltzer, Johannes Schenkel, Wim Declercq, Peter Vandenabeele, Rolf Jaggi |
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| E-Jahr: | 2001 |
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| Jahr: | 6 June 2001 |
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| Umfang: | 10 S. |
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| Teil: | volume:104 |
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| | year:2001 |
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| | number:1 |
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| | pages:89-98 |
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| | extent:10 |
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| Fussnoten: | Gesehen am 06.05.2021 |
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| Titel Quelle: | Enthalten in: Mechanisms of development |
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| Ort Quelle: | Shannon : Elsevier, 1990 |
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| Jahr Quelle: | 2001 |
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| Band/Heft Quelle: | 104(2001), 1, Seite 89-98 |
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| ISSN Quelle: | 1872-6356 |
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| Abstract: | At weaning, milk producing mammary epithelial cells undergo apoptosis and are removed by phagocytosis. Here, we show that mouse mammary gland involution is associated with mitochondrial cytochrome c release and processing of numerous caspases, including caspase-1, -3, -7, -8 and -9. Induction of caspase-3-like activity paralleled cleavage of poly-(ADP-ribose) polymerase. Dexamethasone inhibited processing of caspase-3, -7 and -8 and apoptosis, but had no effect on caspase-1 accumulation and cytochrome c release. In Bcl-2 transgenic animals, cytochrome c release, caspase activation and apoptosis were impaired. Thus, the pro-apoptotic signaling pathway in mammary epithelial cells during involution involves the release of cytochrome c and activation of caspases. It is inhibited by Bcl-2 at the mitochondrial level and by dexamethasone at a post-mitochondrial level. |
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| DOI: | doi:10.1016/S0925-4773(01)00381-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/S0925-4773(01)00381-1 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0925477301003811 |
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| | DOI: https://doi.org/10.1016/S0925-4773(01)00381-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Apoptosis |
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| | Caspase |
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| | Cytochrome |
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| | Involution |
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| | Programmed cell death |
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| K10plus-PPN: | 175721870X |
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| Verknüpfungen: | → Zeitschrift |
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Mouse mammary gland involution is associated with cytochrome c release and caspase activation / Marti, Andreas [VerfasserIn]; 6 June 2001 (Online-Ressource)
