| Online-Ressource |
Verfasst von: | Marti, Andreas [VerfasserIn]  |
| Ritter, Philipp M. [VerfasserIn]  |
| Jäger, Richard [VerfasserIn]  |
| Lazar, Hedvika [VerfasserIn]  |
| Baltzer, Anna [VerfasserIn]  |
| Schenkel, Johannes [VerfasserIn]  |
| Declercq, Wim [VerfasserIn]  |
| Vandenabeele, Peter [VerfasserIn]  |
| Jaggi, Rolf [VerfasserIn]  |
Titel: | Mouse mammary gland involution is associated with cytochrome c release and caspase activation |
Verf.angabe: | Andreas Marti, Philipp M. Ritter, Richard Jäger, Hedvika Lazar, Anna Baltzer, Johannes Schenkel, Wim Declercq, Peter Vandenabeele, Rolf Jaggi |
E-Jahr: | 2001 |
Jahr: | 6 June 2001 |
Umfang: | 10 S. |
Teil: | volume:104 |
| year:2001 |
| number:1 |
| pages:89-98 |
| extent:10 |
Fussnoten: | Gesehen am 06.05.2021 |
Titel Quelle: | Enthalten in: Mechanisms of development |
Ort Quelle: | Shannon : Elsevier, 1990 |
Jahr Quelle: | 2001 |
Band/Heft Quelle: | 104(2001), 1, Seite 89-98 |
ISSN Quelle: | 1872-6356 |
Abstract: | At weaning, milk producing mammary epithelial cells undergo apoptosis and are removed by phagocytosis. Here, we show that mouse mammary gland involution is associated with mitochondrial cytochrome c release and processing of numerous caspases, including caspase-1, -3, -7, -8 and -9. Induction of caspase-3-like activity paralleled cleavage of poly-(ADP-ribose) polymerase. Dexamethasone inhibited processing of caspase-3, -7 and -8 and apoptosis, but had no effect on caspase-1 accumulation and cytochrome c release. In Bcl-2 transgenic animals, cytochrome c release, caspase activation and apoptosis were impaired. Thus, the pro-apoptotic signaling pathway in mammary epithelial cells during involution involves the release of cytochrome c and activation of caspases. It is inhibited by Bcl-2 at the mitochondrial level and by dexamethasone at a post-mitochondrial level. |
DOI: | doi:10.1016/S0925-4773(01)00381-1 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/S0925-4773(01)00381-1 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0925477301003811 |
| DOI: https://doi.org/10.1016/S0925-4773(01)00381-1 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Apoptosis |
| Caspase |
| Cytochrome |
| Involution |
| Programmed cell death |
K10plus-PPN: | 175721870X |
Verknüpfungen: | → Zeitschrift |
Mouse mammary gland involution is associated with cytochrome c release and caspase activation / Marti, Andreas [VerfasserIn]; 6 June 2001 (Online-Ressource)