| |  Online-Ressource |
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| Verfasst von: | Herr, Ingrid [VerfasserIn]  |
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| | Martín-Villalba, Ana [VerfasserIn] |
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| | Kurz, Elke [VerfasserIn] |
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| | Roncaioli, Paola [VerfasserIn] |
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| | Schenkel, Johannes [VerfasserIn] |
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| | Cifone, Maria Grazia [VerfasserIn] |
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| | Debatin, Klaus-Michael [VerfasserIn] |
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| Titel: | FK506 prevents stroke-induced generation of ceramide and apoptosis signaling |
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| Verf.angabe: | Ingrid Herr, Ana Martin-Villalba, Elke Kurz, Paola Roncaioli, Johannes Schenkel, Maria Grazia Cifone, Klaus-Michael Debatin |
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| E-Jahr: | 1999 |
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| Jahr: | 6 April 1999 |
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| Umfang: | 10 S. |
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| Teil: | volume:826 |
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| | year:1999 |
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| | number:2 |
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| | pages:210-219 |
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| | extent:10 |
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| Fussnoten: | Gesehen am 06.05.2021 |
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| Titel Quelle: | Enthalten in: Brain research |
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| Ort Quelle: | Amsterdam : Elsevier, 1966 |
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| Jahr Quelle: | 1999 |
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| Band/Heft Quelle: | 826(1999), 2, Seite 210-219 |
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| ISSN Quelle: | 1872-6240 |
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| Abstract: | Ceramide is a key mediator of apoptosis during the cellular stress response which is also involved in stroke-induced death. Transient occlusion of the middle cerebral artery (MCA) in rats led to a strong generation of ceramide as measured in thalamus and entorhinal cortex of the ischemic brain tissue. Enhanced levels of ceramide may be involved in apoptosis signaling following stroke since exogenously added synthetic C2-ceramide increased expression of c-jun and the death-inducing ligands (DILs) CD95-L, TRAIL and TNF-α in neuroblastoma cells. DILs in turn mediated death via binding to their respective receptors as concluded from diminished apoptosis upon blocking of the common pathway by dominant negative FADD. C2-ceramide induced both necrosis and apoptosis in a concentration-dependent manner corresponding to the situation present in the ischemic brain. The immunosuppressant FK506 inhibited the release of ceramide, expression of CD95-L and apoptosis in an in vitro and in vivo model for ischemia/reperfusion. These data suggest that ceramide is a crucial initiator of death, e.g., by induction of DILs following stroke. |
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| DOI: | doi:10.1016/S0006-8993(99)01288-3 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/S0006-8993(99)01288-3 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0006899399012883 |
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| | DOI: https://doi.org/10.1016/S0006-8993(99)01288-3 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | c- |
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| | CD95-L |
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| | FADD |
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| | Ischemia/reperfusion |
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| | Necrosis |
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| | TNF-α |
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| | Trail |
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| K10plus-PPN: | 1757227032 |
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| Verknüpfungen: | → Zeitschrift |
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FK506 prevents stroke-induced generation of ceramide and apoptosis signaling / Herr, Ingrid [VerfasserIn]; 6 April 1999 (Online-Ressource)
