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| Verfasst von: | Gangkofner, Dominik S. [VerfasserIn]  |
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| | Holzinger, Dana [VerfasserIn] |
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| | Schroeder, Lea [VerfasserIn] |
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| | Eichmüller, Stefan B. [VerfasserIn] |
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| | Zörnig, Inka [VerfasserIn] |
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| | Jäger, Dirk [VerfasserIn] |
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| | Wichmann, Gunnar [VerfasserIn] |
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| | Dietz, Andreas [VerfasserIn] |
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| | Broglie, Martina A. [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| | Dyckhoff, Gerhard [VerfasserIn] |
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| | Boscolo‐Rizzo, Paolo [VerfasserIn] |
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| | Ezic, Jasmin [VerfasserIn] |
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| | Marienfeld, Ralf B. [VerfasserIn] |
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| | Möller, Peter [VerfasserIn] |
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| | Völkel, Gunnar [VerfasserIn] |
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| | Kraus, Johann M. [VerfasserIn] |
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| | Kestler, Hans A. [VerfasserIn] |
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| | Brunner, Cornelia [VerfasserIn] |
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| | Schuler, Patrick J. [VerfasserIn] |
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| | Wigand, Marlene [VerfasserIn] |
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| | Theodoraki, Marie N. [VerfasserIn] |
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| | Doescher, Johannes [VerfasserIn] |
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| | Hoffmann, Thomas K. [VerfasserIn] |
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| | Pawlita, Michael [VerfasserIn] |
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| | Butt, Julia [VerfasserIn] |
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| | Waterboer, Tim [VerfasserIn] |
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| | Laban, Simon Andreas [VerfasserIn] |
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| Titel: | Patterns of antibody responses to nonviral cancer antigens in head and neck squamous cell carcinoma patients differ by human papillomavirus status |
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| Verf.angabe: | Dominik S. Gangkofner, Dana Holzinger, Lea Schroeder, Stefan B. Eichmüller, Inka Zörnig, Dirk Jäger, Gunnar Wichmann, Andreas Dietz, Martina A. Broglie, Christel Herold‐Mende, Gerhard Dyckhoff, Paolo Boscolo‐Rizzo, Jasmin Ezic, Ralf B. Marienfeld, Peter Möller, Gunnar Völkel, Johann M. Kraus, Hans A. Kestler, Cornelia Brunner, Patrick J. Schuler, Marlene Wigand, Marie N. Theodoraki, Johannes Doescher, Thomas K. Hoffmann, Michael Pawlita, Julia Butt, Tim Waterboer, Simon Laban |
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| E-Jahr: | 2019 |
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| Jahr: | 12 August 2019 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 06.05.2021 |
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| Titel Quelle: | Enthalten in: International journal of cancer |
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| Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 145(2019), 12 vom: Dez., Seite 3436-3444 |
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| ISSN Quelle: | 1097-0215 |
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| Abstract: | There have been hints that nonviral cancer antigens are differentially expressed in human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC). Antibody responses (AR) to cancer antigens may be used to indirectly determine cancer antigen expression in the tumor using a noninvasive and tissue-saving liquid biopsy. Here, we set out to characterize AR to a panel of nonviral cancer antigens in HPV-positive and HPV-negative HNSCC patients. A fluorescent microbead multiplex serology to 29 cancer antigens (16 cancer-testis antigens, 5 cancer-retina antigens and 8 oncogenes) and 29 HPV-antigens was performed in 382 HNSCC patients from five independent cohorts (153 HPV-positive and 209 HPV-negative). AR to any of the cancer antigens were found in 272/382 patients (72%). The ten most frequent AR were CT47, cTAGE5a, c-myc, LAGE-1, MAGE-A1, -A3, -A4, NY-ESO-1, SpanX-a1 and p53. AR to MAGE-A3, MAGE-A9 and p53 were found at significantly different prevalences by HPV status. An analysis of AR mean fluorescent intensity values uncovered remarkably different AR clusters by HPV status. To identify optimal antigen selections covering a maximum of patients with ≤10 AR, multiobjective optimization revealed distinct antigen selections by HPV status. We identified that AR to nonviral antigens differ by HPV status indicating differential antigen expression. Multiplex serology may be used to characterize antigen expression using serum or plasma as a tissue-sparing liquid biopsy. Cancer antigen panels should address the distinct antigen repertoire of HPV-positive and HPV-negative HNSCC. |
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| DOI: | doi:10.1002/ijc.32623 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/https://doi.org/10.1002/ijc.32623 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32623 |
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| | DOI: https://doi.org/10.1002/ijc.32623 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | antibodies |
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| | cancer antigens |
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| | head and neck squamous cell carcinoma |
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| | immunotherapy |
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| | vaccination targets |
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| K10plus-PPN: | 1757269622 |
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| Verknüpfungen: | → Zeitschrift |
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Patterns of antibody responses to nonviral cancer antigens in head and neck squamous cell carcinoma patients differ by human papillomavirus status / Gangkofner, Dominik S. [VerfasserIn]; 12 August 2019 (Online-Ressource)
