Prospective evaluation of early treatment outcome in patients with meningiomas treated with particle therapy based on target volume definition with MRI and 68Ga-DOTATOC-PET

• Verfasst von: Combs, Stephanie [VerfasserIn]
• Verfasst von: Welzel, Thomas [VerfasserIn]
• Verfasst von: Habermehl, Daniel [VerfasserIn]
• Verfasst von: Rieken, Stefan [VerfasserIn]
• Verfasst von: Dittmar, Jan Oliver [VerfasserIn]
• Verfasst von: Kessel, Kerstin [VerfasserIn]
• Verfasst von: Jäkel, Oliver [VerfasserIn]
• Verfasst von: Haberkorn, Uwe [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Titel: Prospective evaluation of early treatment outcome in patients with meningiomas treated with particle therapy based on target volume definition with MRI and 68Ga-DOTATOC-PET
• Verf.angabe: Stephanie E. Combs, Thomas Welzel, Daniel Habermehl, Stefan Rieken, Jan-Oliver Dittmar, Kerstin Kessel, Oliver Jäkel, Uwe Haberkorn and Jürgen Debus
• E-Jahr: 2013
• Jahr: 12 Feb 2013
• Umfang: 7 S.
• Teil: volume:52
• Teil: year:2013
• Teil: number:3
• Teil: pages:514-520
• Teil: extent:7
• Fussnoten: Im Titel ist "68" hochgestellt ; Gesehen am 07.05.2021
• Titel Quelle: Enthalten in: Acta oncologica
• Ort Quelle: Abingdon : Taylor & Francis Group, 1987
• Jahr Quelle: 2013
• Band/Heft Quelle: 52(2013), 3, Seite 514-520
• ISSN Quelle: 1651-226X
• DOI: doi:10.3109/0284186X.2013.762996
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1757521283

Abstract

Purpose. To evaluate early treatment results and toxicity in patients with meningiomas treated with particle therapy. Material and methods. Seventy patients with meningiomas were treated with protons (n = 38) or carbon ion radiotherapy (n = 26). Median age was 49 years. Median age at treatment was 55 years, 24 were male (34%), and 46 were female (66%). Histology was benign meningioma in 26 patients (37%), atypical in 23 patients (33%) and anaplastic in four patients (6%). In 17 patients (24%) with skull base meningiomas diagnosis was based on the typical appearance of a meningioma. For benign meningiomas, total doses of 52.2-57.6 GyE were applied with protons. For high-grade lesions, the boost volume was 18 GyE carbon ions, with a median dose of 50 GyE applied as highly conformal radiation therapy. Nineteen patients were treated as re-irradiation. Treatment planning with MRI and 68-Ga-DOTATOC-PET was evaluated. Results. Very low rates of side effects developed, including headaches, nausea and dizziness. No severe treatment-related toxicity was observed. Local control for benign meningiomas was 100%. Five of 27 patients (19%) developed tumor recurrence during follow-up. Of these, four patients had been treated as re-irradiation for recurrent high-risk meningiomas. Actuarial local control after re-irradiation of high-risk meningiomas was therefore 67% at six and 12 months. In patients treated with primary radiotherapy, only one of 13 patients (8%) developed tumor recurrence 17 months after radiation therapy (photon and carbon ion boost). Conclusion. Continuous prospective follow-up and development of novel study concepts are required to fully exploit the long-term clinical data after particle therapy for meningiomas. To date, it may be concluded that when proton therapy is available, meningioma patients can be offered a treatment at least comparable to high-end photon therapy.