| |  Online-Ressource |
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| Verfasst von: | Protopapa, Evangelia [VerfasserIn]  |
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| | Gaissert, Henning A. [VerfasserIn] |
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| | Xenakis, A. [VerfasserIn] |
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| | Avramiotis, S. [VerfasserIn] |
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| | Stavrianeas, N. [VerfasserIn] |
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| | Sekeris, C. E. [VerfasserIn] |
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| | Schenkel, Johannes [VerfasserIn] |
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| | Alonso, Angel [VerfasserIn] |
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| Titel: | The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region |
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| Verf.angabe: | E.E. Protopapa, H. Gaissert, A. Xenakis, S. Avramiotis, N. Stavrianeas, C.E. Sekeris, J. Schenkel, A. Alonso |
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| Jahr: | 1999 |
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| Umfang: | 8 S. |
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| Teil: | volume:13 |
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| | year:1999 |
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| | number:1 |
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| | pages:28-35 |
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| | extent:8 |
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| Fussnoten: | Published: 29 September 2006 ; Gesehen am 10.05.2021 ; Elektronische Reproduktion der Druck-Ausgabe |
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| Titel Quelle: | Enthalten in: European Academy of Dermatology and VenereologyJournal of the European Academy of Dermatology and Venereology |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1991 |
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| Jahr Quelle: | 1999 |
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| Band/Heft Quelle: | 13(1999), 1, Seite 28-35 |
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| ISSN Quelle: | 1468-3083 |
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| Abstract: | OBJECTIVE: To study the effects of proteolytic enzymes on mice hair follicles, particularly on cells of the bulge area regarded as follicle stem cells. - BACKGROUND: Previous application by iontophoresis of proteolytic enzymes on guinea pig skin resulted in degenerative effects on hair follicles and the hypothesis was proposed that some of the affected cells could be stem cells. - METHODS: To mark putative stem cells transgenic mice were produced carrying the lac-Z gene fused to the Upstream Regulatory Region (URR) of Human Papilloma Virus 11 (HPV11), as they express this gene specifically in the cells of the bulge area. Chymotrypsin and papain were applied on skin by iontophoresis, trypsin in the form of liposomes. - RESULTS: Enzyme application, both by electrophoresis and as liposomes, led to intense degenerative effects of the hair follicle, such as detachment of the inner root sheath, cystic dilation of the hair shaft and presence of epithelial cells within the lumen. Some of these cells represent hair follicle stem cells expressing beta-galactosidase (beta-gal), having been detached from the bulge area as a result of enzyme treatment, implying impairment of their function. |
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| DOI: | doi:10.1111/j.1468-3083.1999.tb00840.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag ; Resolving-System: https://doi.org/10.1111/j.1468-3083.1999.tb00840.x |
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| | Volltext: https://pubmed.ncbi.nlm.nih.gov/10565627/ |
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| | DOI: https://doi.org/10.1111/j.1468-3083.1999.tb00840.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | beta-Galactosidase |
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| | Chymotrypsin |
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| | Drug Carriers |
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| | Female |
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| | Hair Follicle |
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| | Iontophoresis |
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| | Liposomes |
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| | Mice |
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| | Mice, Transgenic |
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| | Papain |
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| | Reference Values |
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| K10plus-PPN: | 1757538291 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region / Protopapa, Evangelia [VerfasserIn]; 1999 (Online-Ressource)
