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Verfasst von:Knipper, Sophie [VerfasserIn]   i
 Ascalone, Luigi [VerfasserIn]   i
 Ziegler, Benjamin [VerfasserIn]   i
 Hohenhorst, Jan L. [VerfasserIn]   i
 Simon, Ricarda [VerfasserIn]   i
 Berliner, Christoph [VerfasserIn]   i
 van Leeuwen, Fijs W. B. [VerfasserIn]   i
 van der Poel, Henk [VerfasserIn]   i
 Giesel, Frederik L. [VerfasserIn]   i
 Graefen, Markus [VerfasserIn]   i
 Eiber, Matthias [VerfasserIn]   i
 Heck, Matthias M. [VerfasserIn]   i
 Horn, Thomas [VerfasserIn]   i
 Maurer, Tobias [VerfasserIn]   i
Titel:Salvage surgery in patients with local recurrence after radical prostatectomy
Verf.angabe:Sophie Knipper, Luigi Ascalone, Benjamin Ziegler, Jan L. Hohenhorst, Ricarda Simon, Christoph Berliner, Fijs W.B. van Leeuwen, Henk van der Poel, Frederik Giesel, Markus Graefen, Matthias Eiber, Matthias M. Heck, Thomas Horn, Tobias Maurer
Jahr:2021
Jahr des Originals:2020
Umfang:8 S.
Teil:volume:79
 year:2021
 number:4
 pages:537-544
 extent:8
Fussnoten:Available online 11 December 2020 ; Gesehen am 10.05.2021
Titel Quelle:Enthalten in: European urology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1976
Jahr Quelle:2021
Band/Heft Quelle:79(2021), 4, Seite 537-544
ISSN Quelle:1873-7560
 1421-993X
Abstract:Background - Since the introduction of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging, isolated local recurrence after radical prostatectomy (RP) can be delineated accurately. - Objective - To describe and evaluate surgical technique, biochemical response, and therapy-free survival (TFS) after salvage surgery in patients with local recurrence in the seminal vesicle bed. - Design, setting, and participants - We retrospectively assessed 40 patients treated with open salvage surgery in two centres (11/2014-02/2020). All patients presented with biochemical recurrence (BCR) after RP with a singular local recurrence at PSMA PET imaging. Thirty-three (82.5%) patients received previous salvage radiation therapy. - Surgical procedure - Open salvage surgery with PSMA radioguidance. - Measurements - Prostate-specific antigen (PSA) nadir and percentage of patients with complete biochemical response (cBR) without further treatment (PSA < 0.2 ng/ml) after 6-16 wk were assessed. BCR-free survival and TFS were calculated using Kaplan-Meier estimates. Clavien-Dindo complications were evaluated. - Results and limitations - Prior to salvage surgery, median PSA was 0.9 ng/ml (interquartile range [IQR]: 0.5-1.7 ng/ml). Postoperatively, median PSA nadir was 0.1 ng/ml (IQR: 0-0.4 ng/ml). In 31 (77.5%) patients, cBR was observed. During the median follow-up of 24.4 months, 22 (55.0%) patients experienced BCR and 12 (30.0%) received further therapy. At 1 yr of follow-up, BCR-free survival rate was 62.2% and TFS rate was 88.3%. Three (7.5%) Clavien-Dindo grade III complications were observed. The main limitations are the retrospective design, short follow-up, and lack of a control group. - Conclusions - Salvage surgery of local recurrence within the seminal vesicle bed is feasible. It may present an opportunity in selected, locally recurrent patients to prolong BCR-free survival and increase TFS. Further studies are needed to confirm our findings. - Patient summary - We looked at the outcomes from prostate cancer patients with locally recurrent disease after radical prostatectomy and radiotherapy. We found that surgery in well-selected patients may be an opportunity to prolong treatment-free survival.
DOI:doi:10.1016/j.eururo.2020.11.012
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.eururo.2020.11.012
 Volltext: https://www.sciencedirect.com/science/article/pii/S0302283820308769
 DOI: https://doi.org/10.1016/j.eururo.2020.11.012
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Biochemical recurrence
 Prostate cancer
 Prostate-specific antigen
 Prostate-specific membrane antigen
 Radioguided surgery
 Seminal vesicles
K10plus-PPN:1757550062
Verknüpfungen:→ Zeitschrift

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