| |  Online-Ressource |
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| Verfasst von: | Colpitts, Che C. [VerfasserIn]  |
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| | Ridewood, Sophie [VerfasserIn] |
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| | Schneiderman, Bethany [VerfasserIn] |
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| | Warne, Justin [VerfasserIn] |
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| | Tabata, Keisuke [VerfasserIn] |
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| | Ng, Caitlin F. [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| | Selwood, David L. [VerfasserIn] |
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| | Towers, Greg J. [VerfasserIn] |
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| Titel: | Hepatitis C virus exploits cyclophilin A to evade PKR |
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| Verf.angabe: | Che C. Colpitts, Sophie Ridewood, Bethany Schneiderman, Justin Warne, Keisuke Tabata, Caitlin F. Ng, Ralf Bartenschlager, David L. Selwood, Greg J. Towers |
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| E-Jahr: | 2020 |
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| Jahr: | June 16, 2020 |
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| Umfang: | 25 S. |
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| Teil: | volume:9 |
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| | year:2020 |
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| | month:06 |
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| | elocationid:e52237 |
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| | pages:1-25 |
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| | extent:25 |
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| Fussnoten: | Gesehen am 10.05.2021 |
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| Titel Quelle: | Enthalten in: eLife |
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| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 9(2020) vom: Juni, Artikel-ID e52237, Seite 1-25 |
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| ISSN Quelle: | 2050-084X |
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| Abstract: | Counteracting innate immunity is essential for successful viral replication. Host cyclophilins (Cyps) have been implicated in viral evasion of host antiviral responses, although the mechanisms are still unclear. Here, we show that hepatitis C virus (HCV) co-opts the host protein CypA to aid evasion of antiviral responses dependent on the effector protein kinase R (PKR). Pharmacological inhibition of CypA rescues PKR from antagonism by HCV NS5A, leading to activation of an interferon regulatory factor-1 (IRF1)-driven cell intrinsic antiviral program that inhibits viral replication. These findings further the understanding of the complexity of Cyp-virus interactions, provide mechanistic insight into the remarkably broad antiviral spectrum of Cyp inhibitors, and uncover novel aspects of PKR activity and regulation. Collectively, our study identifies a novel antiviral mechanism that harnesses cellular antiviral immunity to suppress viral replication. |
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| DOI: | doi:10.7554/eLife.52237 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.52237 |
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| | DOI: https://doi.org/10.7554/eLife.52237 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cyclosporine-a |
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| | expression |
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| | gene delivery |
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| | inhibitors |
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| | interferon |
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| | isomerase activity |
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| | ns5a |
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| | protein-kinase |
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| | replication |
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| | rna-binding |
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| K10plus-PPN: | 1757584331 |
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| Verknüpfungen: | → Zeitschrift |
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Hepatitis C virus exploits cyclophilin A to evade PKR / Colpitts, Che C. [VerfasserIn]; June 16, 2020 (Online-Ressource)
