Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:González-González, Ana I. [VerfasserIn]   i
 Dinh, Truc S. [VerfasserIn]   i
 Meid, Andreas [VerfasserIn]   i
 Blom, Jeanet W. [VerfasserIn]   i
 van den Akker, Marjan [VerfasserIn]   i
 Elders, Petra J. M. [VerfasserIn]   i
 Thiem, Ulrich [VerfasserIn]   i
 Kuellenberg de Gaudry, Daniela [VerfasserIn]   i
 Snell, Kym I. E. [VerfasserIn]   i
 Perera, Rafael [VerfasserIn]   i
 Swart, Karin M. A. [VerfasserIn]   i
 Rudolf, Henrik [VerfasserIn]   i
 Bosch-Lenders, Donna [VerfasserIn]   i
 Trampisch, Hans-Joachim [VerfasserIn]   i
 Meerpohl, Joerg J. [VerfasserIn]   i
 Flaig, Benno [VerfasserIn]   i
 Kom, Ghainsom [VerfasserIn]   i
 Gerlach, Ferdinand M. [VerfasserIn]   i
 Haefeli, Walter E. [VerfasserIn]   i
 Glasziou, Paul P. [VerfasserIn]   i
 Muth, Christiane [VerfasserIn]   i
Titel:Predicting negative health outcomes in older general practice patients with chronic illness
Titelzusatz:Rationale and development of the PROPERmed harmonized individual participant data database
Verf.angabe:Ana I. González-González, Truc S. Dinh, Andreas D. Meid, Jeanet W. Blom, Marjan van den Akker, Petra J. M. Elders, Ulrich Thiem, Daniela Kuellenberg de Gaudry, Kym I. E. Snell, Rafael Perera, Karin M. A. Swart, Henrik Rudolf, Donna Bosch-Lenders, Hans-Joachim Trampisch, Joerg J. Meerpohl, Benno Flaig, Ghainsom Kom, Ferdinand M. Gerlach, Walter E. Hafaeli, Paul P. Glasziou, Christiane Muth
E-Jahr:2021
Jahr:15 January 2021
Umfang:11 S.
Teil:volume:194
 year:2021
 month:03
 elocationid:111436
 pages:1-11
 extent:11
Fussnoten:Gesehen am 12.05.2021
Titel Quelle:Enthalten in: Mechanisms of ageing and development
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1972
Jahr Quelle:2021
Band/Heft Quelle:194(2021) vom: März, Artikel-ID 111436, Seite 1-11
ISSN Quelle:1872-6216
Abstract:The prevalence of multimorbidity and polypharmacy increases significantly with age and are associated with negative health consequences. However, most current interventions to optimize medication have failed to show significant effects on patient-relevant outcomes. This may be due to ineffectiveness of interventions themselves but may also reflect other factors: insufficient sample sizes, heterogeneity of population. To address this issue, the international PROPERmed collaboration was set up to obtain/synthesize individual participant data (IPD) from five cluster-randomized trials. The trials took place in Germany and The Netherlands and aimed to optimize medication in older general practice patients with chronic illness. PROPERmed is the first database of IPD to be drawn from multiple trials in this patient population and setting. It offers the opportunity to derive prognostic models with increased statistical power for prediction of patient-relevant outcomes resulting from the interplay of multimorbidity and polypharmacy. This may help patients from this heterogeneous group to be stratified according to risk and enable clinicians to identify patients that are likely to benefit most from resource/time-intensive interventions. The aim of this manuscript is to describe the rationale behind PROPERmed collaboration, characteristics of the included studies/participants, development of the harmonized IPD database and challenges faced during this process.
DOI:doi:10.1016/j.mad.2021.111436
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.mad.2021.111436
 Volltext: https://www.sciencedirect.com/science/article/pii/S0047637421000087
 DOI: https://doi.org/10.1016/j.mad.2021.111436
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Elderly
 Hospitalization
 Meta-analysis
 Multimorbidity
 Polypharmacy
 Prognosis
 Quality of life
K10plus-PPN:1757701249
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68737179   QR-Code
zum Seitenanfang