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Verfasst von:Wolf, Robert Christian [VerfasserIn]   i
 Rashidi, Mahmoud [VerfasserIn]   i
 Schmitgen, Mike [VerfasserIn]   i
 Fritze, Stefan [VerfasserIn]   i
 Sambataro, Fabio [VerfasserIn]   i
 Kubera, Katharina Maria [VerfasserIn]   i
 Hirjak, Dusan [VerfasserIn]   i
Titel:Neurological soft signs predict auditory verbal hallucinations in patients with schizophrenia
Verf.angabe:Robert C. Wolf, Mahmoud Rashidi, Mike M. Schmitgen, Stefan Fritze, Fabio Sambataro, Katharina M. Kubera, and Dusan Hirjak
Jahr:2021
Jahr des Originals:2020
Umfang:11 S.
Fussnoten:Gesehen am 12.05.2021 ; First published: 24 October 2020
Titel Quelle:Enthalten in: Schizophrenia bulletin
Ort Quelle:Oxford : Oxford Univ. Press, 1969
Jahr Quelle:2021
Band/Heft Quelle:47(2021), 2 vom: März, Seite 433-443
ISSN Quelle:1745-1701
Abstract:Neurological soft signs (NSS) are well documented in individuals with schizophrenia (SZ), yet so far, the relationship between NSS and specific symptom expression is unclear. We studied 76 SZ patients using magnetic resonance imaging (MRI) to determine associations between NSS, positive symptoms, gray matter volume (GMV), and neural activity at rest. SZ patients were hypothesis-driven stratified according to the presence or absence of auditory verbal hallucinations (AVH; n = 34 without vs 42 with AVH) according to the Brief Psychiatric Rating Scale. Structural MRI data were analyzed using voxel-based morphometry, whereas intrinsic neural activity was investigated using regional homogeneity (ReHo) measures. Using ANCOVA, AVH patients showed significantly higher NSS in motor and integrative functions (IF) compared with non-hallucinating (nAVH) patients. Partial correlation revealed that NSS IF were positively associated with AVH symptom severity in AVH patients. Such associations were not confirmed for delusions. In region-of-interest ANCOVAs comprising the left middle and superior temporal gyri, right paracentral lobule, and right inferior parietal lobule (IPL) structure and function, significant differences between AVH and nAVH subgroups were not detected. In a binary logistic regression model, IF scores and right IPL ReHo were significant predictors of AVH. These data suggest significant interrelationships between sensorimotor integration abilities, brain structure and function, and AVH symptom expression.
DOI:doi:10.1093/schbul/sbaa146
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1093/schbul/sbaa146
 DOI: https://doi.org/10.1093/schbul/sbaa146
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1757704035
Verknüpfungen:→ Zeitschrift

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