| |  Online-Ressource |
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| Verfasst von: | Sainz, Juan [VerfasserIn]  |
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| | García-Verdejo, Francisco José [VerfasserIn] |
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| | Martínez-Bueno, Manuel [VerfasserIn] |
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| | Kumar, Abhishek [VerfasserIn] |
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| | Sánchez-Maldonado, José Manuel [VerfasserIn] |
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| | Díez-Villanueva, Anna [VerfasserIn] |
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| | Vodičková, Ludmila [VerfasserIn] |
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| | Vymetálková, Veronika [VerfasserIn] |
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| | Martin Sánchez, Vicente [VerfasserIn] |
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| | Silva Filho, Miguel Inacio da [VerfasserIn] |
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| | Sampaio-Marques, Belém [VerfasserIn] |
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| | Brezina, Stefanie [VerfasserIn] |
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| | Butterbach, Katja [VerfasserIn] |
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| | ter Horst, Rob [VerfasserIn] |
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| | Hoffmeister, Michael [VerfasserIn] |
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| | Ludovico, Paula [VerfasserIn] |
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| | Jurado, Manuel [VerfasserIn] |
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| | Li, Yang [VerfasserIn] |
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| | Sánchez-Rovira, Pedro [VerfasserIn] |
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| | Netea, Mihai G. [VerfasserIn] |
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| | Gsur, Andrea [VerfasserIn] |
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| | Vodička, Pavel [VerfasserIn] |
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| | Moreno, Víctor [VerfasserIn] |
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| | Hemminki, Kari [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| | Chang-Claude, Jenny [VerfasserIn] |
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| | Försti, Asta [VerfasserIn] |
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| Titel: | Polymorphisms within autophagy-related genes influence the risk of developing colorectal cancer |
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| Titelzusatz: | a meta-analysis of four large cohorts |
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| Verf.angabe: | Juan Sainz, Francisco José García-Verdejo, Manuel Martínez-Bueno, Abhishek Kumar, José Manuel Sánchez-Maldonado, Anna Díez-Villanueva, Ludmila Vodičková, Veronika Vymetálková, Vicente Martin Sánchez, Miguel Inacio Da Silva Filho, Belém Sampaio-Marques, Stefanie Brezina, Katja Butterbach, Rob ter Horst, Michael Hoffmeister, Paula Ludovico, Manuel Jurado, Yang Li, Pedro Sánchez-Rovira, Mihai G. Netea, Andrea Gsur, Pavel Vodička, Víctor Moreno, Kari Hemminki, Hermann Brenner, Jenny Chang-Claude and Asta Försti |
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| E-Jahr: | 2021 |
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| Jahr: | 2 March 2021 |
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| Umfang: | 16 S. |
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| Teil: | volume:13 |
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| | year:2021 |
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| | number:6 |
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| | elocationid:1258 |
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| | pages:1-16 |
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| | extent:16 |
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| Fussnoten: | Gesehen am 12.05.2021 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 6, Artikel-ID 1258, Seite 1-16 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | The role of genetic variation in autophagy-related genes in modulating autophagy and cancer is poorly understood. Here, we comprehensively investigated the association of autophagy-related variants with colorectal cancer (CRC) risk and provide new insights about the molecular mechanisms underlying the associations. After meta-analysis of the genome-wide association study (GWAS) data from four independent European cohorts (8006 CRC cases and 7070 controls), two loci, DAPK2 (p = 2.19 × 10−5) and ATG5 (p = 6.28 × 10−4) were associated with the risk of CRC. Mechanistically, the DAPK2rs11631973G allele was associated with IL1 β levels after the stimulation of peripheral blood mononuclear cells (PBMCs) with Staphylococcus aureus (p = 0.002), CD24 + CD38 + CD27 + IgM + B cell levels in blood (p = 0.0038) and serum levels of en-RAGE (p = 0.0068). ATG5rs546456T allele was associated with TNF α and IL1 β levels after the stimulation of PBMCs with LPS (p = 0.0088 and p = 0.0076, respectively), CD14+CD16− cell levels in blood (p = 0.0068) and serum levels of CCL19 and cortisol (p = 0.0052 and p = 0.0074, respectively). Interestingly, no association with autophagy flux was observed. These results suggested an effect of the DAPK2 and ATG5 loci in the pathogenesis of CRC, likely through the modulation of host immune responses. |
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| DOI: | doi:10.3390/cancers13061258 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers13061258 |
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| | Volltext: https://www.mdpi.com/2072-6694/13/6/1258 |
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| | DOI: https://doi.org/10.3390/cancers13061258 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | autophagy |
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| | colorectal cancer |
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| | genetic variants |
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| | susceptibility |
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| K10plus-PPN: | 1757713964 |
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| Verknüpfungen: | → Zeitschrift |
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Polymorphisms within autophagy-related genes influence the risk of developing colorectal cancer / Sainz, Juan [VerfasserIn]; 2 March 2021 (Online-Ressource)
